FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042027599> ?p ?o ?g. }

• W2042027599 endingPage "497" @default.
• W2042027599 startingPage "490" @default.
• W2042027599 abstract "Background Septic shock is characterized by arterial and venous dilatation and decreased responsiveness to vasoconstrictors. We have developed a method to explore the effects and mechanisms of action of administration of endotoxin into a blood vessel in vivo. Methods and Results Endotoxin was instilled into a dorsal hand vein for 1 hour and then removed. A dose-response curve to norepinephrine was constructed before and 1, 2, 3, and 4 hours after endotoxin. In a separate study, dose-response curves to norepinephrine were constructed in two separate veins on the same hand, only one of which received endotoxin. Sympathetic-mediated venoconstrictor responses were also studied. Cyclooxygenase inhibitors, nitric oxide synthase inhibitors, and hydrocortisone were used to explore the mechanisms of the effects seen. Endotoxin caused a rightward shift in the dose-response curve to norepinephrine. The effect was greatest at 1 hour (maximal constriction: before endotoxin, 87±4%; after endotoxin, 52±8%; n=4; P <.05) and returned to normal by 4 hours. In addition, deep-breath venoconstrictor responses were abolished in the endotoxin-treated vein. Instillation of endotoxin daily for 3 days resulted in the development of tolerance (maximal constriction to norepinephrine after endotoxin: day 1, 39±6%; day 2, 67±7%; day 3, 85±7%). Cyclooxygenase and/or nitric oxide synthase inhibitors did not alter the response to endotoxin, whereas prior administration of hydrocortisone abolished the effects. Conclusions Instillation of endotoxin caused a glucocorticoid-inhibitable hyporesponsiveness to the constrictor effects of norepinephrine and abolished sympathetically induced and drug-induced venoconstriction. This acute response does not appear to be mediated by nitric oxide or prostanoids. Direct vascular tolerance to endotoxin occurs on repeated administration." @default.
• W2042027599 created "2016-06-24" @default.
• W2042027599 creator A5018179985 @default.
• W2042027599 creator A5044594207 @default.
• W2042027599 creator A5073267685 @default.
• W2042027599 date "1996-08-01" @default.
• W2042027599 modified "2023-09-26" @default.
• W2042027599 title "Local Venous Responses to Endotoxin in Humans" @default.
• W2042027599 cites W1212704 @default.
• W2042027599 cites W1800127744 @default.
• W2042027599 cites W1977179549 @default.
• W2042027599 cites W1977897227 @default.
• W2042027599 cites W1997632401 @default.
• W2042027599 cites W2003153577 @default.
• W2042027599 cites W2009194142 @default.
• W2042027599 cites W2018870992 @default.
• W2042027599 cites W2024283446 @default.
• W2042027599 cites W2035988892 @default.
• W2042027599 cites W2046888117 @default.
• W2042027599 cites W2050129788 @default.
• W2042027599 cites W2053056168 @default.
• W2042027599 cites W2063074934 @default.
• W2042027599 cites W2067338751 @default.
• W2042027599 cites W2068882878 @default.
• W2042027599 cites W2072145356 @default.
• W2042027599 cites W2073677792 @default.
• W2042027599 cites W2077930151 @default.
• W2042027599 cites W2081441884 @default.
• W2042027599 cites W2085834535 @default.
• W2042027599 cites W2092620816 @default.
• W2042027599 cites W2093600357 @default.
• W2042027599 cites W2094054594 @default.
• W2042027599 cites W2122515902 @default.
• W2042027599 cites W2125642970 @default.
• W2042027599 cites W2146948320 @default.
• W2042027599 cites W2169737919 @default.
• W2042027599 cites W2177210292 @default.
• W2042027599 cites W2200198236 @default.
• W2042027599 cites W2285969917 @default.
• W2042027599 cites W2305117137 @default.
• W2042027599 cites W2318065544 @default.
• W2042027599 cites W2319070317 @default.
• W2042027599 cites W2329925936 @default.
• W2042027599 cites W2331264491 @default.
• W2042027599 cites W2416905730 @default.
• W2042027599 cites W2419629552 @default.
• W2042027599 doi "https://doi.org/10.1161/01.cir.94.3.490" @default.
• W2042027599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8759094" @default.
• W2042027599 hasPublicationYear "1996" @default.
• W2042027599 type Work @default.
• W2042027599 sameAs 2042027599 @default.
• W2042027599 citedByCount "58" @default.
• W2042027599 countsByYear W20420275992012 @default.
• W2042027599 countsByYear W20420275992014 @default.
• W2042027599 countsByYear W20420275992021 @default.
• W2042027599 crossrefType "journal-article" @default.
• W2042027599 hasAuthorship W2042027599A5018179985 @default.
• W2042027599 hasAuthorship W2042027599A5044594207 @default.
• W2042027599 hasAuthorship W2042027599A5073267685 @default.
• W2042027599 hasConcept C126322002 @default.
• W2042027599 hasConcept C134018914 @default.
• W2042027599 hasConcept C174940676 @default.
• W2042027599 hasConcept C181199279 @default.
• W2042027599 hasConcept C185592680 @default.
• W2042027599 hasConcept C2777202286 @default.
• W2042027599 hasConcept C2777622882 @default.
• W2042027599 hasConcept C2777628635 @default.
• W2042027599 hasConcept C2778384902 @default.
• W2042027599 hasConcept C2778514916 @default.
• W2042027599 hasConcept C2778709874 @default.
• W2042027599 hasConcept C2779689624 @default.
• W2042027599 hasConcept C2779961880 @default.
• W2042027599 hasConcept C2780841215 @default.
• W2042027599 hasConcept C2781300812 @default.
• W2042027599 hasConcept C42219234 @default.
• W2042027599 hasConcept C513476851 @default.
• W2042027599 hasConcept C519581460 @default.
• W2042027599 hasConcept C55493867 @default.
• W2042027599 hasConcept C71924100 @default.
• W2042027599 hasConcept C98274493 @default.
• W2042027599 hasConceptScore W2042027599C126322002 @default.
• W2042027599 hasConceptScore W2042027599C134018914 @default.
• W2042027599 hasConceptScore W2042027599C174940676 @default.
• W2042027599 hasConceptScore W2042027599C181199279 @default.
• W2042027599 hasConceptScore W2042027599C185592680 @default.
• W2042027599 hasConceptScore W2042027599C2777202286 @default.
• W2042027599 hasConceptScore W2042027599C2777622882 @default.
• W2042027599 hasConceptScore W2042027599C2777628635 @default.
• W2042027599 hasConceptScore W2042027599C2778384902 @default.
• W2042027599 hasConceptScore W2042027599C2778514916 @default.
• W2042027599 hasConceptScore W2042027599C2778709874 @default.
• W2042027599 hasConceptScore W2042027599C2779689624 @default.
• W2042027599 hasConceptScore W2042027599C2779961880 @default.
• W2042027599 hasConceptScore W2042027599C2780841215 @default.
• W2042027599 hasConceptScore W2042027599C2781300812 @default.
• W2042027599 hasConceptScore W2042027599C42219234 @default.
• W2042027599 hasConceptScore W2042027599C513476851 @default.
• W2042027599 hasConceptScore W2042027599C519581460 @default.

• next