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- W2042032304 abstract "The conditions and mechanisms of the action of a number of drugs on the non-cytotoxic concentrations on the in vitro cytotoxic effect (CE)∗ of immune lymphocytes have been studied. Pronase and heparin appeared to be the most powerful inhibitors of CE, phospholipase C was ineffective, neuraminidase amplified CE when target cells were pretreated. The initial step of immune lymphocyte interaction with target cells completed by the specific lymphocyte absorption was inhibited entirely by pronase, partially by trypsin and Vi-polysaccharide, was not inhibited by heparin, trypan blue, chlorochin and prednisolon and was enhanced by neuraminidase. The pronase action was completely reversible. Heparin affected only overall byt not specific lymphocyte-target contact and suppressed blast percentage growth subsequent to this contact. The conclusive step of interaction, target cell destruction, has been inhibited by pronase and lysosome-active drugs (trypan blue, chlorochin, prednisolon). The latter did not affect either overall or specific lymphocyte absorption or an increase of blast percentage during incubation with appropriate target cells." @default.
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- W2042032304 date "1973-03-01" @default.
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- W2042032304 title "Modification of in vitro immune lymphocyte-target cell interaction by some biologically active drugs" @default.
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- W2042032304 doi "https://doi.org/10.1016/0019-2791(73)90006-2" @default.
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