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• W2042033702 abstract "The present study investigated the effects of high levels of estradiol in female rats on four different radial arm maze tasks: the hippocampus-dependent spatial working-reference memory task; the prefrontal cortex–hippocampus dependent delayed win-shift task; the striatum-dependent cued win-stay task; and the amygdala-dependent conditioned place preference task. Ovariectomized female rats were injected daily with either 10 μg of estradiol benzoate or sesame oil vehicle ∼4 h prior to testing. In Experiment 1, treatment with estradiol disrupted learning on the spatial working-reference memory task by increasing the number of reference memory errors to reach criterion. In Experiment 2, treatment with estradiol had no significant effect on the delayed win-shift task. In Experiment 3, treatment with estradiol resulted in impaired performance on a striatum-dependent cued win-stay task. In Experiment 4, treatment with estradiol impaired the acquisition of a conditioned place-preference task. Taken together these findings suggest that high levels of estradiol inhibit reference memory, stimulus response learning, and amygdala-dependent appetitive conditioning while having little effect on working memory." @default.
• W2042033702 created "2016-06-24" @default.
• W2042033702 creator A5022988545 @default.
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• W2042033702 date "2001-11-29" @default.
• W2042033702 modified "2023-10-16" @default.
• W2042033702 title "High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory" @default.
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• W2042033702 doi "https://doi.org/10.1016/s0166-4328(01)00255-8" @default.
• W2042033702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11704257" @default.
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