FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042056421> ?p ?o ?g. }

• W2042056421 endingPage "459" @default.
• W2042056421 startingPage "447" @default.
• W2042056421 abstract "Numerous approaches to cell transplantation of the hepatic or the extrahepatic origin into liver tissue have been developed; however, the efficiency of cell transplantation remains low and liver functions are not well corrected. The liver is a highly immunoreactive organ that contains many resident macrophages known as Kupffer cells. Here, we show that the inhibition of Kupffer cell activity improves stem cell transplantation into liver tissue and corrects some of the liver functions under conditions of liver injury. We found that, when Kupffer cells were inhibited by glycine, numerous adipose-derived stem cells (ASCs) were successfully transplanted into livers, and these transplanted cells showed hepatoprotective effects, including decrease of liver injury factors, increase of liver regeneration, and albumin production. On the contrary, injected ASCs without glycine recruited numerous Kupffer cells, not lymphocytes, and showed low transplantation efficiency. Intriguingly, successfully transplanted ASCs in liver tissue modulated Kupffer cell activity to inhibit tumor necrosis factor-α secretion. Thus, our data show that Kupffer cell inactivation is an important step in order to improve ASC transplantation efficiency and therapeutic potential in liver injuries. In addition, the hepatoprotective function of glycine has synergic effects on liver protection and the engraftment of ASCs." @default.
• W2042056421 created "2016-06-24" @default.
• W2042056421 creator A5006088354 @default.
• W2042056421 creator A5013654282 @default.
• W2042056421 creator A5015561923 @default.
• W2042056421 creator A5022962284 @default.
• W2042056421 creator A5040222459 @default.
• W2042056421 creator A5041079397 @default.
• W2042056421 creator A5043695659 @default.
• W2042056421 creator A5044956866 @default.
• W2042056421 creator A5055682088 @default.
• W2042056421 creator A5070522565 @default.
• W2042056421 creator A5075254528 @default.
• W2042056421 creator A5078493599 @default.
• W2042056421 date "2013-03-01" @default.
• W2042056421 modified "2023-10-18" @default.
• W2042056421 title "Inhibition of Kupffer Cell Activity Improves Transplantation of Human Adipose-Derived Stem Cells and Liver Functions" @default.
• W2042056421 cites W1597038591 @default.
• W2042056421 cites W1842800599 @default.
• W2042056421 cites W1894580504 @default.
• W2042056421 cites W1964060084 @default.
• W2042056421 cites W1967466647 @default.
• W2042056421 cites W1974323483 @default.
• W2042056421 cites W1981787940 @default.
• W2042056421 cites W1986796350 @default.
• W2042056421 cites W1994667536 @default.
• W2042056421 cites W2005943573 @default.
• W2042056421 cites W2013758266 @default.
• W2042056421 cites W2014824982 @default.
• W2042056421 cites W2017200989 @default.
• W2042056421 cites W2018572283 @default.
• W2042056421 cites W2023375304 @default.
• W2042056421 cites W2027158916 @default.
• W2042056421 cites W2028471442 @default.
• W2042056421 cites W2030667183 @default.
• W2042056421 cites W2038173176 @default.
• W2042056421 cites W2039129365 @default.
• W2042056421 cites W2044875340 @default.
• W2042056421 cites W2047718984 @default.
• W2042056421 cites W2051297632 @default.
• W2042056421 cites W2052766825 @default.
• W2042056421 cites W2057887260 @default.
• W2042056421 cites W2062101834 @default.
• W2042056421 cites W2063281955 @default.
• W2042056421 cites W2075348465 @default.
• W2042056421 cites W2080836140 @default.
• W2042056421 cites W2085959104 @default.
• W2042056421 cites W2087353148 @default.
• W2042056421 cites W2089592611 @default.
• W2042056421 cites W2090497358 @default.
• W2042056421 cites W2092696109 @default.
• W2042056421 cites W2095666785 @default.
• W2042056421 cites W2104193042 @default.
• W2042056421 cites W2107503723 @default.
• W2042056421 cites W2108352524 @default.
• W2042056421 cites W2111727066 @default.
• W2042056421 cites W2118458879 @default.
• W2042056421 cites W2121051882 @default.
• W2042056421 cites W2123389370 @default.
• W2042056421 cites W2125525909 @default.
• W2042056421 cites W2126134953 @default.
• W2042056421 cites W2138946470 @default.
• W2042056421 cites W2139016106 @default.
• W2042056421 cites W2140511951 @default.
• W2042056421 cites W2148173491 @default.
• W2042056421 cites W2158129157 @default.
• W2042056421 cites W2161820725 @default.
• W2042056421 cites W2161905225 @default.
• W2042056421 cites W2164740133 @default.
• W2042056421 cites W2339061968 @default.
• W2042056421 doi "https://doi.org/10.3727/096368912x640583" @default.
• W2042056421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22546493" @default.
• W2042056421 hasPublicationYear "2013" @default.
• W2042056421 type Work @default.
• W2042056421 sameAs 2042056421 @default.
• W2042056421 citedByCount "7" @default.
• W2042056421 countsByYear W20420564212014 @default.
• W2042056421 countsByYear W20420564212015 @default.
• W2042056421 countsByYear W20420564212016 @default.
• W2042056421 countsByYear W20420564212017 @default.
• W2042056421 countsByYear W20420564212018 @default.
• W2042056421 crossrefType "journal-article" @default.
• W2042056421 hasAuthorship W2042056421A5006088354 @default.
• W2042056421 hasAuthorship W2042056421A5013654282 @default.
• W2042056421 hasAuthorship W2042056421A5015561923 @default.
• W2042056421 hasAuthorship W2042056421A5022962284 @default.
• W2042056421 hasAuthorship W2042056421A5040222459 @default.
• W2042056421 hasAuthorship W2042056421A5041079397 @default.
• W2042056421 hasAuthorship W2042056421A5043695659 @default.
• W2042056421 hasAuthorship W2042056421A5044956866 @default.
• W2042056421 hasAuthorship W2042056421A5055682088 @default.
• W2042056421 hasAuthorship W2042056421A5070522565 @default.
• W2042056421 hasAuthorship W2042056421A5075254528 @default.
• W2042056421 hasAuthorship W2042056421A5078493599 @default.
• W2042056421 hasConcept C126322002 @default.
• W2042056421 hasConcept C134018914 @default.
• W2042056421 hasConcept C142724271 @default.
• W2042056421 hasConcept C171089720 @default.

• next