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- W2042085140 abstract "Abstract Zanamivir, laninamivir, and CS‐8958 are three neuraminidase inhibitors that have been clinically used to combat influenza. We report herein a novel organocatalytic route for preparing these agents. Only 13 steps are needed for the assembly of zanamivir and laninamivir from inexpensive D ‐araboascorbic acid by this synthetic route, which relies heavily on a thiourea‐catalyzed enantioselective Michael addition of acetone to tert ‐butyl (2‐nitrovinyl)carbamate and an anti ‐selective Henry reaction of the resulting Michael adduct with an aldehyde prepared from D ‐araboascorbic acid. The synthetic procedures are scalable, as evident from the preparation of more than 3.5 g of zanamivir." @default.
- W2042085140 created "2016-06-24" @default.
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- W2042085140 date "2014-10-14" @default.
- W2042085140 modified "2023-10-18" @default.
- W2042085140 title "Organocatalytic and Scalable Synthesis of the Anti-Influenza Drugs Zanamivir, Laninamivir, and CS-8958" @default.
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- W2042085140 doi "https://doi.org/10.1002/anie.201408138" @default.
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