FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042091064> ?p ?o ?g. }

• W2042091064 endingPage "2910" @default.
• W2042091064 startingPage "2905" @default.
• W2042091064 abstract "Abstract Recently, the copper efflux transporters ATP7B and ATP7A have been implicated in the transport of and resistance to platinum drugs in breast and ovarian cancers. Because of the extensive use of oxaliplatin in colorectal cancer (CRC), we examined the expression of both transporters in tumors from CRC patients treated with oxaliplatin/5FU and sought to determine whether their expression can predict clinical outcome in these patients. ATP7B and ATP7A levels were determined by quantitative real‐time PCR in 50 primary tumors of previously untreated patients with advanced colorectal adenocarcinoma who were subsequently treated with oxaliplatin/5FU. Additionally, ATP7B protein expression was assessed by immunohistochemical staining using a tissue microarray. Patients with the lowest mRNA expression levels of ATP7B had a significantly longer time to progression (TTP) ( p = 0.0009) than patients with the highest levels (12.14 months vs . 6.43 months) who also had an increased risk of progression (HR = 3.56; 95% CI, 1.6–7.9; p = 0.002). Furthermore, patients with low levels of both protein and mRNA of ATP7B derived the maximum benefit from oxaliplatin/5FU with the longest TTP as compared with patients with high levels of ATP7B protein and mRNA (14.64 months vs . 4.63 months, respectively, p = 0.01) and showed a nonsignificant trend toward a lower response rate (37.5% and 75%, respectively). In conclusion, ATP7B mRNA and protein expression in colorectal tumors is associated with clinical outcome to oxaliplatin/5FU. Prospective studies are required to evaluate the role of this marker in tailoring chemotherapy. © 2009 UICC" @default.
• W2042091064 created "2016-06-24" @default.
• W2042091064 creator A5023220693 @default.
• W2042091064 creator A5032860719 @default.
• W2042091064 creator A5036588901 @default.
• W2042091064 creator A5046072298 @default.
• W2042091064 creator A5053944948 @default.
• W2042091064 creator A5054297951 @default.
• W2042091064 creator A5057435612 @default.
• W2042091064 creator A5060753118 @default.
• W2042091064 creator A5068189051 @default.
• W2042091064 date "2009-03-18" @default.
• W2042091064 modified "2023-10-10" @default.
• W2042091064 title "Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin-based chemotherapy" @default.
• W2042091064 cites W1970122162 @default.
• W2042091064 cites W1982217309 @default.
• W2042091064 cites W2000402876 @default.
• W2042091064 cites W2010355719 @default.
• W2042091064 cites W2014966556 @default.
• W2042091064 cites W2019617397 @default.
• W2042091064 cites W2026712007 @default.
• W2042091064 cites W2034615295 @default.
• W2042091064 cites W2053923285 @default.
• W2042091064 cites W2091720578 @default.
• W2042091064 cites W2096747288 @default.
• W2042091064 cites W2097334193 @default.
• W2042091064 cites W2113689159 @default.
• W2042091064 cites W2124392685 @default.
• W2042091064 cites W2126898944 @default.
• W2042091064 cites W2130177169 @default.
• W2042091064 cites W2134224836 @default.
• W2042091064 cites W2134363913 @default.
• W2042091064 cites W2136615414 @default.
• W2042091064 cites W2138693913 @default.
• W2042091064 cites W2139840013 @default.
• W2042091064 cites W2153906296 @default.
• W2042091064 cites W2158678426 @default.
• W2042091064 cites W2170454539 @default.
• W2042091064 doi "https://doi.org/10.1002/ijc.24273" @default.
• W2042091064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19296535" @default.
• W2042091064 hasPublicationYear "2009" @default.
• W2042091064 type Work @default.
• W2042091064 sameAs 2042091064 @default.
• W2042091064 citedByCount "54" @default.
• W2042091064 countsByYear W20420910642012 @default.
• W2042091064 countsByYear W20420910642013 @default.
• W2042091064 countsByYear W20420910642014 @default.
• W2042091064 countsByYear W20420910642015 @default.
• W2042091064 countsByYear W20420910642016 @default.
• W2042091064 countsByYear W20420910642017 @default.
• W2042091064 countsByYear W20420910642018 @default.
• W2042091064 countsByYear W20420910642019 @default.
• W2042091064 countsByYear W20420910642020 @default.
• W2042091064 countsByYear W20420910642021 @default.
• W2042091064 countsByYear W20420910642022 @default.
• W2042091064 countsByYear W20420910642023 @default.
• W2042091064 crossrefType "journal-article" @default.
• W2042091064 hasAuthorship W2042091064A5023220693 @default.
• W2042091064 hasAuthorship W2042091064A5032860719 @default.
• W2042091064 hasAuthorship W2042091064A5036588901 @default.
• W2042091064 hasAuthorship W2042091064A5046072298 @default.
• W2042091064 hasAuthorship W2042091064A5053944948 @default.
• W2042091064 hasAuthorship W2042091064A5054297951 @default.
• W2042091064 hasAuthorship W2042091064A5057435612 @default.
• W2042091064 hasAuthorship W2042091064A5060753118 @default.
• W2042091064 hasAuthorship W2042091064A5068189051 @default.
• W2042091064 hasBestOaLocation W20420910641 @default.
• W2042091064 hasConcept C104317684 @default.
• W2042091064 hasConcept C121608353 @default.
• W2042091064 hasConcept C126322002 @default.
• W2042091064 hasConcept C143998085 @default.
• W2042091064 hasConcept C149011108 @default.
• W2042091064 hasConcept C193270364 @default.
• W2042091064 hasConcept C204232928 @default.
• W2042091064 hasConcept C2776694085 @default.
• W2042091064 hasConcept C2778260052 @default.
• W2042091064 hasConcept C2780962732 @default.
• W2042091064 hasConcept C44312359 @default.
• W2042091064 hasConcept C512196 @default.
• W2042091064 hasConcept C526805850 @default.
• W2042091064 hasConcept C55493867 @default.
• W2042091064 hasConcept C71924100 @default.
• W2042091064 hasConcept C86803240 @default.
• W2042091064 hasConcept C90924648 @default.
• W2042091064 hasConceptScore W2042091064C104317684 @default.
• W2042091064 hasConceptScore W2042091064C121608353 @default.
• W2042091064 hasConceptScore W2042091064C126322002 @default.
• W2042091064 hasConceptScore W2042091064C143998085 @default.
• W2042091064 hasConceptScore W2042091064C149011108 @default.
• W2042091064 hasConceptScore W2042091064C193270364 @default.
• W2042091064 hasConceptScore W2042091064C204232928 @default.
• W2042091064 hasConceptScore W2042091064C2776694085 @default.
• W2042091064 hasConceptScore W2042091064C2778260052 @default.
• W2042091064 hasConceptScore W2042091064C2780962732 @default.
• W2042091064 hasConceptScore W2042091064C44312359 @default.
• W2042091064 hasConceptScore W2042091064C512196 @default.
• W2042091064 hasConceptScore W2042091064C526805850 @default.
• W2042091064 hasConceptScore W2042091064C55493867 @default.

• next