Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042094248> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2042094248 endingPage "207" @default.
- W2042094248 startingPage "197" @default.
- W2042094248 abstract "Preparations of isolated rat jejunal enterocyte and brush-border and basolateral membrane vesicles have been used to study the effects of a 15 min exposure of upper and mid-villus enterocytes to pancreatic glucagon on the initial, unidirectional phlorhizin-sensitive (brush border) transport of galactose and phlorhizin-insensitive (basolateral) movement of the sugar. These acute effects of glucagon have been compared with responses following treatment of animals for 1 or 3 days with the hormone. Incubation of cells with glucagon significantly stimulated phlorhizin-sensitive uptake by 42 and 64% for upper and mid-villus cells, respectively. Glucagon, however, was without effect on phlorhizin-insensitive galactose uptake. This differential action of the hormone at the two cellular loci was confirmed by uptake data obtained using purified brush-border and basolateral membrane vesicles prepared from isolated cells. In contrast to the acute challenge with glucagon, treatment of animals for 3 days with the hormone significantly increased both phlorizin-sensitive (upper villus +31%, mid-villus +74%) and phlorizin-insensitive (upper villus +42%, mid-villus +53%) galactose uptake. Glucagon exposure of exposure of isolated cells from 3 days treated animals was without further effect on galactose uptake at the two membrane loci. These data represent the first evidence for a direct action of pancreatic glucagon on enterocyte sugar transport. Thus the hormone is likely to be important in the physiological control of sugar absorption in addition to its possible role in the modulation of transport during starvation and diabetes mellitus, conditions characterized by hyperglucanonaemia and enhanced intestinal sugar transport." @default.
- W2042094248 created "2016-06-24" @default.
- W2042094248 creator A5019923510 @default.
- W2042094248 creator A5083513543 @default.
- W2042094248 date "1993-03-01" @default.
- W2042094248 modified "2023-09-25" @default.
- W2042094248 title "Acute and chronic effects of pancreatic glucagon on sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes" @default.
- W2042094248 doi "https://doi.org/10.1113/expphysiol.1993.sp003680" @default.
- W2042094248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8471240" @default.
- W2042094248 hasPublicationYear "1993" @default.
- W2042094248 type Work @default.
- W2042094248 sameAs 2042094248 @default.
- W2042094248 citedByCount "33" @default.
- W2042094248 countsByYear W20420942482012 @default.
- W2042094248 countsByYear W20420942482015 @default.
- W2042094248 countsByYear W20420942482016 @default.
- W2042094248 crossrefType "journal-article" @default.
- W2042094248 hasAuthorship W2042094248A5019923510 @default.
- W2042094248 hasAuthorship W2042094248A5083513543 @default.
- W2042094248 hasBestOaLocation W20420942481 @default.
- W2042094248 hasConcept C126322002 @default.
- W2042094248 hasConcept C130316041 @default.
- W2042094248 hasConcept C134018914 @default.
- W2042094248 hasConcept C1491633281 @default.
- W2042094248 hasConcept C161573976 @default.
- W2042094248 hasConcept C185592680 @default.
- W2042094248 hasConcept C2777866211 @default.
- W2042094248 hasConcept C2777882243 @default.
- W2042094248 hasConcept C2778117581 @default.
- W2042094248 hasConcept C2778173381 @default.
- W2042094248 hasConcept C2778563252 @default.
- W2042094248 hasConcept C2779306644 @default.
- W2042094248 hasConcept C2779604457 @default.
- W2042094248 hasConcept C39587587 @default.
- W2042094248 hasConcept C41625074 @default.
- W2042094248 hasConcept C5426402 @default.
- W2042094248 hasConcept C55493867 @default.
- W2042094248 hasConcept C71315377 @default.
- W2042094248 hasConcept C71924100 @default.
- W2042094248 hasConcept C86803240 @default.
- W2042094248 hasConceptScore W2042094248C126322002 @default.
- W2042094248 hasConceptScore W2042094248C130316041 @default.
- W2042094248 hasConceptScore W2042094248C134018914 @default.
- W2042094248 hasConceptScore W2042094248C1491633281 @default.
- W2042094248 hasConceptScore W2042094248C161573976 @default.
- W2042094248 hasConceptScore W2042094248C185592680 @default.
- W2042094248 hasConceptScore W2042094248C2777866211 @default.
- W2042094248 hasConceptScore W2042094248C2777882243 @default.
- W2042094248 hasConceptScore W2042094248C2778117581 @default.
- W2042094248 hasConceptScore W2042094248C2778173381 @default.
- W2042094248 hasConceptScore W2042094248C2778563252 @default.
- W2042094248 hasConceptScore W2042094248C2779306644 @default.
- W2042094248 hasConceptScore W2042094248C2779604457 @default.
- W2042094248 hasConceptScore W2042094248C39587587 @default.
- W2042094248 hasConceptScore W2042094248C41625074 @default.
- W2042094248 hasConceptScore W2042094248C5426402 @default.
- W2042094248 hasConceptScore W2042094248C55493867 @default.
- W2042094248 hasConceptScore W2042094248C71315377 @default.
- W2042094248 hasConceptScore W2042094248C71924100 @default.
- W2042094248 hasConceptScore W2042094248C86803240 @default.
- W2042094248 hasIssue "2" @default.
- W2042094248 hasLocation W20420942481 @default.
- W2042094248 hasLocation W20420942482 @default.
- W2042094248 hasOpenAccess W2042094248 @default.
- W2042094248 hasPrimaryLocation W20420942481 @default.
- W2042094248 hasRelatedWork W130249857 @default.
- W2042094248 hasRelatedWork W2006513370 @default.
- W2042094248 hasRelatedWork W2037205718 @default.
- W2042094248 hasRelatedWork W2042094248 @default.
- W2042094248 hasRelatedWork W2048327266 @default.
- W2042094248 hasRelatedWork W2083094630 @default.
- W2042094248 hasRelatedWork W2096420073 @default.
- W2042094248 hasRelatedWork W2150937124 @default.
- W2042094248 hasRelatedWork W2187001057 @default.
- W2042094248 hasRelatedWork W2410784692 @default.
- W2042094248 hasVolume "78" @default.
- W2042094248 isParatext "false" @default.
- W2042094248 isRetracted "false" @default.
- W2042094248 magId "2042094248" @default.
- W2042094248 workType "article" @default.