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• W2042100028 abstract "Abstract In the phospholipase‐C (PLC) signaling system, Ca 2+ is mobilized from intracellular Ca 2+ stores by an action of inositol 1,4,5‐trisphosphate (IP 3 ). The depletion of IP 3 ‐sensitive Ca 2+ stores activates a store‐operated Ca 2+ entry (SOCE). However, no direct evidence has been obtained about these signaling pathways in odontoblasts. In this study, we investigate the characteristics of the SOCE and IP 3 ‐mediated Ca 2+ mobilizations in rat odontoblasts using fura‐2 microfluorometry and a nystatin‐perforated patch‐clamp technique. In the absence of extracellular Ca 2+ ([Ca 2+ ] o ), thapsigargin (TG) evoked a transient rise in intracellular Ca 2+ concentration ([Ca 2+ ] i ). After TG treatment to deplete the store, the subsequent application of Ca 2+ resulted in a rapid rise in [Ca 2+ ] i caused by SOCE. In the absence of TG treatment, no SOCE was evoked. The Ca 2+ influx was dependent on [Ca 2+ ] o ( K D = 1.29 mM) and was blocked by an IP 3 receptor inhibitor, 2‐aminoethoxydiphenyl borate (2‐APB), as well as La 3+ in a concentration‐dependent manner (IC 50 = 26 μM). In TG‐treated cells, an elevation of [Ca 2+ ] o from 0 to 2.5 mM elicited an inwardly rectifying current at hyperpolarizing potentials with a positive reversal potential. The currents were selective for Ca 2+ over the other divalent cations (Ca 2+ > Ba 2+ > Sr 2+ ≫ Mn 2+ ). In the absence of [Ca 2+ ] o , carbachol, bradykinin, and 2‐methylthioadenosine 5′triphosphate activated Ca 2+ release from the store; these were inhibited by 2‐APB. These results indicate that odontoblasts possessed Ca 2+ signaling pathways through the activation of store‐operated Ca 2+ channels by the depletion of intracellular Ca 2+ stores and through the IP 3 ‐induced Ca 2+ release activated by PLC‐coupled receptors." @default.
• W2042100028 created "2016-06-24" @default.
• W2042100028 creator A5037788866 @default.
• W2042100028 creator A5080059055 @default.
• W2042100028 date "2003-01-01" @default.
• W2042100028 modified "2023-10-11" @default.
• W2042100028 title "Ca2+ Signaling Mediated by IP3-Dependent Ca2+ Releasing and Store-Operated Ca2+ Channels in Rat Odontoblasts" @default.
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• W2042100028 doi "https://doi.org/10.1359/jbmr.2003.18.1.30" @default.
• W2042100028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12510803" @default.
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