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- W2042100114 abstract "Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in the treatment of diabetes, but without induction of anti-insulin antibodies. Recently, corosolic acid from Lagerstroemia speciosa L. leaf extracts has been reported to act via an indirect mechanism (unlike insulin) in animal experiments. The insulin-complementary anti-diabetic therapeutic value observed in these Japanese preliminary clinical trials has led to renewed interest in the biosynthesis of this compound. So far, there has been no clear evidence for a corosolic acid biosynthetic pathway in plants. This article provides possible roles of corosolic acid and hypothetical information on the biosynthetic pathway in plants." @default.
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- W2042100114 date "2009-12-01" @default.
- W2042100114 modified "2023-09-30" @default.
- W2042100114 title "Plant-based corosolic acid: Future anti-diabetic drug?" @default.
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- W2042100114 doi "https://doi.org/10.1002/biot.200900207" @default.
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