FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042107029> ?p ?o ?g. }

• W2042107029 endingPage "58" @default.
• W2042107029 startingPage "53" @default.
• W2042107029 abstract "The pharmacokinetics (PK) and pharmacodynamics (PD) of marbofloxacin were established in calves for six strains of each of the pneumonia pathogens Mannheimia haemolytica and Pasteurella multocida. The distribution of marbofloxacin into inflamed (exudate) and non-inflamed (transudate) tissue cage fluids allowed comparison with the serum concentration–time profile. To establish the PD profile, minimum inhibitory concentration (MIC) was determined in Mueller–Hinton broth (MHB) and calf serum. Moderately higher MICs were obtained for serum compared to MHB. An initial integration of PK–PD data established Cmax/MIC ratios of 45.0 and AUC24h/MIC values of 174.7 h, based on serum MICs, for both bacterial species. Using bacterial time-kill curves, generated ex vivo for serum marbofloxacin concentrations, PK–PD modelling established three levels of growth inhibition: AUC24h/MIC ratios for no reduction, 3 log10 and 4 log10 reductions in bacterial count from the initial inoculum count were 41.9, 59.5 and 68.0 h for M. haemolytica and 48.6, 64.9 and 74.8 h for P. multocida, on average respectively. Inter-strain variability for 3 log10 and 4 log10 reductions in bacterial count was smaller for P. multocida than for M. haemolytica. In conjunction with literature data on MIC90 values, the present results allowed prediction of dosages for efficacy for each organism for the three levels of growth inhibition." @default.
• W2042107029 created "2016-06-24" @default.
• W2042107029 creator A5004091210 @default.
• W2042107029 creator A5007405150 @default.
• W2042107029 creator A5012309224 @default.
• W2042107029 creator A5032052958 @default.
• W2042107029 creator A5079065058 @default.
• W2042107029 date "2013-01-01" @default.
• W2042107029 modified "2023-09-28" @default.
• W2042107029 title "Pharmacokinetic and pharmacodynamic integration and modelling of marbofloxacin in calves for Mannheimia haemolytica and Pasteurella multocida" @default.
• W2042107029 cites W1960433349 @default.
• W2042107029 cites W1967816847 @default.
• W2042107029 cites W1981471842 @default.
• W2042107029 cites W1984161829 @default.
• W2042107029 cites W1987106907 @default.
• W2042107029 cites W2009310588 @default.
• W2042107029 cites W2014210153 @default.
• W2042107029 cites W2019341206 @default.
• W2042107029 cites W2033817520 @default.
• W2042107029 cites W2037156603 @default.
• W2042107029 cites W2037633500 @default.
• W2042107029 cites W2041352285 @default.
• W2042107029 cites W2043271015 @default.
• W2042107029 cites W2062360058 @default.
• W2042107029 cites W2068301725 @default.
• W2042107029 cites W2094900450 @default.
• W2042107029 cites W2107772504 @default.
• W2042107029 cites W2115950843 @default.
• W2042107029 cites W2117014230 @default.
• W2042107029 cites W2117690729 @default.
• W2042107029 cites W2117970889 @default.
• W2042107029 cites W2120135710 @default.
• W2042107029 cites W2135034362 @default.
• W2042107029 cites W2147264575 @default.
• W2042107029 cites W2417949110 @default.
• W2042107029 doi "https://doi.org/10.1016/j.tvjl.2012.08.027" @default.
• W2042107029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23084327" @default.
• W2042107029 hasPublicationYear "2013" @default.
• W2042107029 type Work @default.
• W2042107029 sameAs 2042107029 @default.
• W2042107029 citedByCount "32" @default.
• W2042107029 countsByYear W20421070292013 @default.
• W2042107029 countsByYear W20421070292015 @default.
• W2042107029 countsByYear W20421070292016 @default.
• W2042107029 countsByYear W20421070292017 @default.
• W2042107029 countsByYear W20421070292018 @default.
• W2042107029 countsByYear W20421070292019 @default.
• W2042107029 countsByYear W20421070292020 @default.
• W2042107029 countsByYear W20421070292021 @default.
• W2042107029 countsByYear W20421070292022 @default.
• W2042107029 countsByYear W20421070292023 @default.
• W2042107029 crossrefType "journal-article" @default.
• W2042107029 hasAuthorship W2042107029A5004091210 @default.
• W2042107029 hasAuthorship W2042107029A5007405150 @default.
• W2042107029 hasAuthorship W2042107029A5012309224 @default.
• W2042107029 hasAuthorship W2042107029A5032052958 @default.
• W2042107029 hasAuthorship W2042107029A5079065058 @default.
• W2042107029 hasBestOaLocation W20421070292 @default.
• W2042107029 hasConcept C111113717 @default.
• W2042107029 hasConcept C112705442 @default.
• W2042107029 hasConcept C176947019 @default.
• W2042107029 hasConcept C192285135 @default.
• W2042107029 hasConcept C22979827 @default.
• W2042107029 hasConcept C2776796551 @default.
• W2042107029 hasConcept C2778573061 @default.
• W2042107029 hasConcept C2778716008 @default.
• W2042107029 hasConcept C42972112 @default.
• W2042107029 hasConcept C4937899 @default.
• W2042107029 hasConcept C523546767 @default.
• W2042107029 hasConcept C54355233 @default.
• W2042107029 hasConcept C59822182 @default.
• W2042107029 hasConcept C71924100 @default.
• W2042107029 hasConcept C86803240 @default.
• W2042107029 hasConcept C89423630 @default.
• W2042107029 hasConcept C98274493 @default.
• W2042107029 hasConceptScore W2042107029C111113717 @default.
• W2042107029 hasConceptScore W2042107029C112705442 @default.
• W2042107029 hasConceptScore W2042107029C176947019 @default.
• W2042107029 hasConceptScore W2042107029C192285135 @default.
• W2042107029 hasConceptScore W2042107029C22979827 @default.
• W2042107029 hasConceptScore W2042107029C2776796551 @default.
• W2042107029 hasConceptScore W2042107029C2778573061 @default.
• W2042107029 hasConceptScore W2042107029C2778716008 @default.
• W2042107029 hasConceptScore W2042107029C42972112 @default.
• W2042107029 hasConceptScore W2042107029C4937899 @default.
• W2042107029 hasConceptScore W2042107029C523546767 @default.
• W2042107029 hasConceptScore W2042107029C54355233 @default.
• W2042107029 hasConceptScore W2042107029C59822182 @default.
• W2042107029 hasConceptScore W2042107029C71924100 @default.
• W2042107029 hasConceptScore W2042107029C86803240 @default.
• W2042107029 hasConceptScore W2042107029C89423630 @default.
• W2042107029 hasConceptScore W2042107029C98274493 @default.
• W2042107029 hasIssue "1" @default.
• W2042107029 hasLocation W20421070291 @default.
• W2042107029 hasLocation W20421070292 @default.
• W2042107029 hasLocation W20421070293 @default.
• W2042107029 hasOpenAccess W2042107029 @default.
• W2042107029 hasPrimaryLocation W20421070291 @default.

• next