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- W2042113410 abstract "Live attenuated vaccines have recently been introduced for preventing rotavirus disease in children. However, alternative strategies for prevention and treatment of rotavirus infection are needed mainly in developing countries where low vaccine coverage occurs. In the present work, N-acetylcysteine (NAC), ascorbic acid (AA), some nonsteroidal anti-inflammatory drugs (NSAIDs) and peroxisome proliferator-activated receptor gamma (PPARγ) agonists were tested for their ability to interfere with rotavirus ECwt infectivity as detected by the percentage of viral antigen-positive cells of small intestinal villi isolated from ECwt-infected ICR mice. Administration of 6 mg NAC/kg every 8 h for three days following the first diarrhoeal episode reduced viral infectivity by about 90%. Administration of AA, ibuprofen, diclofenac, pioglitazone or rosiglitazone decreased viral infectivity by about 55%, 90%, 35%, 32% and 25%, respectively. ECwt infection of mice increased expression of cyclooxygenase-2, ERp57, Hsc70, NF-κB, Hsp70, protein disulphide isomerase (PDI) and PPARγ in intestinal villus cells. NAC treatment of ECwt-infected mice reduced Hsc70 and PDI expression to levels similar to those observed in villi from uninfected control mice. The present results suggest that the drugs tested in the present work could be assayed in preventing or treating rotaviral diarrhoea in children and young animals." @default.
- W2042113410 created "2016-06-24" @default.
- W2042113410 creator A5011611468 @default.
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- W2042113410 creator A5038460640 @default.
- W2042113410 date "2013-09-01" @default.
- W2042113410 modified "2023-10-16" @default.
- W2042113410 title "Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors" @default.
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- W2042113410 doi "https://doi.org/10.1590/0074-0276108062013011" @default.
- W2042113410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3970679" @default.
- W2042113410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24037197" @default.
- W2042113410 hasPublicationYear "2013" @default.
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