Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042137630> ?p ?o ?g. }
- W2042137630 endingPage "1811" @default.
- W2042137630 startingPage "1802" @default.
- W2042137630 abstract "A prospective multicenter program was performed to evaluate the combination of rituximab and high-dose (hd) sequential chemotherapy delivered with multiple autologous peripheral blood progenitor cell (PBPC) support (R-HDS-maps regimen) in previously untreated patients with diffuse large B-cell lymphoma (DLB-CL) and age-adjusted International Prognostic Score (aaIPI) score 2-3. R-HDS-maps includes: (i) three APO courses; (ii) sequential administration of hd-cyclophosphamide (CY), hd-Ara-C, both supplemented with rituximab, hd-etoposide/cisplatin, PBPC harvests, following hd-CY and hd-Ara-C; (iii) hd-mitoxantrone (hd-Mito)/L-Pam + 2 further rituximab doses; (iv) involved-field radiotherapy. PBPC rescue was scheduled following Ara-C, etoposide/cisplatin and Mito/L-Pam. Between 1999 and 2004, 112 consecutive patients aged <65 years (74 score 2, 38 score 3) entered the study protocol. There were five early and two late toxic deaths. Overall 90 patients (80%) reached clinical remission (CR); at a median 48 months follow-up, 87 (78%) patients are alive, 82 (73%) in continuous CR, with 4 year overall survival (OS) and event-free survival (EFS) projections of 76% (CI 68-85%) and 73% (CI 64-81%), respectively. There were no significant differences in OS and EFS between subgroups with Germinal-Center and Activated B-cell phenotype. Thus, life expectancy of younger patients with aaIPI 2-3 DLB-CL is improved with the early administration of rituximab-supplemented intensive chemotherapy compared with the poor outcome following conventional chemotherapy." @default.
- W2042137630 created "2016-06-24" @default.
- W2042137630 creator A5000147101 @default.
- W2042137630 creator A5002995578 @default.
- W2042137630 creator A5005319283 @default.
- W2042137630 creator A5008887695 @default.
- W2042137630 creator A5015840872 @default.
- W2042137630 creator A5016760892 @default.
- W2042137630 creator A5017832164 @default.
- W2042137630 creator A5018139001 @default.
- W2042137630 creator A5021697445 @default.
- W2042137630 creator A5026242819 @default.
- W2042137630 creator A5030934542 @default.
- W2042137630 creator A5049410134 @default.
- W2042137630 creator A5058765211 @default.
- W2042137630 creator A5059155373 @default.
- W2042137630 creator A5059515934 @default.
- W2042137630 creator A5069410590 @default.
- W2042137630 creator A5073352185 @default.
- W2042137630 creator A5074069337 @default.
- W2042137630 creator A5076353357 @default.
- W2042137630 creator A5077428267 @default.
- W2042137630 creator A5082094987 @default.
- W2042137630 creator A5087294312 @default.
- W2042137630 creator A5087360250 @default.
- W2042137630 creator A5088853218 @default.
- W2042137630 creator A5090334148 @default.
- W2042137630 creator A5091482039 @default.
- W2042137630 date "2007-06-07" @default.
- W2042137630 modified "2023-10-12" @default.
- W2042137630 title "Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximab-supplemented, early-intensified chemotherapy with multiple autologous hematopoietic stem cell support: a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi)" @default.
- W2042137630 cites W131909702 @default.
- W2042137630 cites W1901299664 @default.
- W2042137630 cites W1912693401 @default.
- W2042137630 cites W1939946230 @default.
- W2042137630 cites W1979940042 @default.
- W2042137630 cites W1990066058 @default.
- W2042137630 cites W1991006874 @default.
- W2042137630 cites W1994634831 @default.
- W2042137630 cites W1996838958 @default.
- W2042137630 cites W2000143004 @default.
- W2042137630 cites W2020751729 @default.
- W2042137630 cites W2021878902 @default.
- W2042137630 cites W2028905830 @default.
- W2042137630 cites W2029747163 @default.
- W2042137630 cites W2037604512 @default.
- W2042137630 cites W2038465924 @default.
- W2042137630 cites W2043104155 @default.
- W2042137630 cites W2043799126 @default.
- W2042137630 cites W2046011209 @default.
- W2042137630 cites W2049794466 @default.
- W2042137630 cites W2051055769 @default.
- W2042137630 cites W2058015212 @default.
- W2042137630 cites W2059990028 @default.
- W2042137630 cites W2063809730 @default.
- W2042137630 cites W2068937729 @default.
- W2042137630 cites W2077832231 @default.
- W2042137630 cites W2084080138 @default.
- W2042137630 cites W2087510327 @default.
- W2042137630 cites W2096470130 @default.
- W2042137630 cites W2096494849 @default.
- W2042137630 cites W2100404595 @default.
- W2042137630 cites W2107202569 @default.
- W2042137630 cites W2118935462 @default.
- W2042137630 cites W2128313210 @default.
- W2042137630 cites W2131311832 @default.
- W2042137630 cites W2131508403 @default.
- W2042137630 cites W2131904409 @default.
- W2042137630 cites W2142334769 @default.
- W2042137630 cites W2145549056 @default.
- W2042137630 cites W2153230421 @default.
- W2042137630 cites W2153294987 @default.
- W2042137630 cites W2158267770 @default.
- W2042137630 cites W2160305510 @default.
- W2042137630 cites W2160354848 @default.
- W2042137630 cites W2167571754 @default.
- W2042137630 cites W2168438686 @default.
- W2042137630 cites W2179059618 @default.
- W2042137630 cites W2231970192 @default.
- W2042137630 cites W2327882300 @default.
- W2042137630 cites W2330208698 @default.
- W2042137630 cites W2339293928 @default.
- W2042137630 cites W329934425 @default.
- W2042137630 cites W4205736005 @default.
- W2042137630 cites W4238329799 @default.
- W2042137630 cites W4293241248 @default.
- W2042137630 doi "https://doi.org/10.1038/sj.leu.2404781" @default.
- W2042137630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17554382" @default.
- W2042137630 hasPublicationYear "2007" @default.
- W2042137630 type Work @default.
- W2042137630 sameAs 2042137630 @default.
- W2042137630 citedByCount "65" @default.
- W2042137630 countsByYear W20421376302012 @default.
- W2042137630 countsByYear W20421376302013 @default.
- W2042137630 countsByYear W20421376302014 @default.
- W2042137630 countsByYear W20421376302015 @default.
- W2042137630 countsByYear W20421376302016 @default.
- W2042137630 countsByYear W20421376302017 @default.