FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042140280> ?p ?o ?g. }

• W2042140280 endingPage "194" @default.
• W2042140280 startingPage "185" @default.
• W2042140280 abstract "Abstract: Rhythm generation within the mammalian circadian system is achieved by clock genes and their protein products. As an integral part of this system, the pineal gland serves the need to tune the body to the temporal environment by the rhythmic synthesis and release of melatonin. A number of human disorders and syndromes are associated with alterations in circadian rhythms of clock genes and their protein products and/or a dysfunction in melatonin synthesis. In the human, little is known about the molecular signature of time management. Pineal tissue from regular autopsies was allocated to asserted time-of-death groups (dawn, day, dusk, night), and analyzed by RT-PCR, immunoblotting, immunohistochemistry, and confocal laser scanning microscopy for expression of clock genes. Despite the observed diurnal rhythms in activity of the arylalkylamine N-acetyltransferase and in melatonin content, mRNA levels for the clock genes Period1, Cryptochrome1, Clock, and Bmal1, and also amounts of corresponding clock gene proteins showed no differences between time- of-death groups. In contrast, a time-of-day-dependent nucleocytoplasmic shuttling of clock gene proteins was detected. These data confirm the minor importance of a transcriptional regulation for dynamics in the human pineal gland, and offer a novel twist in the molecular competence of clock gene proteins." @default.
• W2042140280 created "2016-06-24" @default.
• W2042140280 creator A5017309005 @default.
• W2042140280 creator A5041205033 @default.
• W2042140280 creator A5052497026 @default.
• W2042140280 creator A5059655475 @default.
• W2042140280 creator A5080092163 @default.
• W2042140280 date "2007-09-01" @default.
• W2042140280 modified "2023-09-25" @default.
• W2042140280 title "Day?night expression patterns of clock genes in the human pineal gland" @default.
• W2042140280 cites W1484949748 @default.
• W2042140280 cites W1517562156 @default.
• W2042140280 cites W1540104393 @default.
• W2042140280 cites W1541117554 @default.
• W2042140280 cites W1646267184 @default.
• W2042140280 cites W1961435330 @default.
• W2042140280 cites W1974736479 @default.
• W2042140280 cites W1990664861 @default.
• W2042140280 cites W1993994649 @default.
• W2042140280 cites W2003302378 @default.
• W2042140280 cites W2006426774 @default.
• W2042140280 cites W2013046951 @default.
• W2042140280 cites W2016068379 @default.
• W2042140280 cites W2020587065 @default.
• W2042140280 cites W2021607553 @default.
• W2042140280 cites W2022759634 @default.
• W2042140280 cites W2027222274 @default.
• W2042140280 cites W2033351913 @default.
• W2042140280 cites W2037830660 @default.
• W2042140280 cites W2049571136 @default.
• W2042140280 cites W2064889359 @default.
• W2042140280 cites W2072942401 @default.
• W2042140280 cites W2073145669 @default.
• W2042140280 cites W2080663355 @default.
• W2042140280 cites W2082351155 @default.
• W2042140280 cites W2090829912 @default.
• W2042140280 cites W2097883984 @default.
• W2042140280 cites W2102955989 @default.
• W2042140280 cites W2115377255 @default.
• W2042140280 cites W2123914447 @default.
• W2042140280 cites W2130935086 @default.
• W2042140280 cites W2137414457 @default.
• W2042140280 cites W2139588443 @default.
• W2042140280 cites W2142393219 @default.
• W2042140280 cites W2144620826 @default.
• W2042140280 cites W2151599212 @default.
• W2042140280 cites W2167389860 @default.
• W2042140280 cites W2168753438 @default.
• W2042140280 cites W2169220425 @default.
• W2042140280 cites W4245694795 @default.
• W2042140280 doi "https://doi.org/10.1111/j.1600-079x.2007.00461.x" @default.
• W2042140280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17645697" @default.
• W2042140280 hasPublicationYear "2007" @default.
• W2042140280 type Work @default.
• W2042140280 sameAs 2042140280 @default.
• W2042140280 citedByCount "24" @default.
• W2042140280 countsByYear W20421402802013 @default.
• W2042140280 countsByYear W20421402802014 @default.
• W2042140280 countsByYear W20421402802016 @default.
• W2042140280 countsByYear W20421402802018 @default.
• W2042140280 countsByYear W20421402802019 @default.
• W2042140280 countsByYear W20421402802020 @default.
• W2042140280 countsByYear W20421402802021 @default.
• W2042140280 countsByYear W20421402802022 @default.
• W2042140280 crossrefType "journal-article" @default.
• W2042140280 hasAuthorship W2042140280A5017309005 @default.
• W2042140280 hasAuthorship W2042140280A5041205033 @default.
• W2042140280 hasAuthorship W2042140280A5052497026 @default.
• W2042140280 hasAuthorship W2042140280A5059655475 @default.
• W2042140280 hasAuthorship W2042140280A5080092163 @default.
• W2042140280 hasConcept C104317684 @default.
• W2042140280 hasConcept C121446783 @default.
• W2042140280 hasConcept C126322002 @default.
• W2042140280 hasConcept C134018914 @default.
• W2042140280 hasConcept C144543706 @default.
• W2042140280 hasConcept C150194340 @default.
• W2042140280 hasConcept C165864922 @default.
• W2042140280 hasConcept C184738001 @default.
• W2042140280 hasConcept C2778182776 @default.
• W2042140280 hasConcept C2780059843 @default.
• W2042140280 hasConcept C38606739 @default.
• W2042140280 hasConcept C54355233 @default.
• W2042140280 hasConcept C71924100 @default.
• W2042140280 hasConcept C86803240 @default.
• W2042140280 hasConcept C95444343 @default.
• W2042140280 hasConceptScore W2042140280C104317684 @default.
• W2042140280 hasConceptScore W2042140280C121446783 @default.
• W2042140280 hasConceptScore W2042140280C126322002 @default.
• W2042140280 hasConceptScore W2042140280C134018914 @default.
• W2042140280 hasConceptScore W2042140280C144543706 @default.
• W2042140280 hasConceptScore W2042140280C150194340 @default.
• W2042140280 hasConceptScore W2042140280C165864922 @default.
• W2042140280 hasConceptScore W2042140280C184738001 @default.
• W2042140280 hasConceptScore W2042140280C2778182776 @default.
• W2042140280 hasConceptScore W2042140280C2780059843 @default.
• W2042140280 hasConceptScore W2042140280C38606739 @default.
• W2042140280 hasConceptScore W2042140280C54355233 @default.
• W2042140280 hasConceptScore W2042140280C71924100 @default.

• next