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• W2042155386 abstract "Contents Plasmatic concentrations of von W illebrand F actor (v WF ) increase during pregnancy in humans and dogs; however the mechanism of such increase is still not well defined. The aims of this study were: (i) to evaluate changes in v WF concentration during pregnancy and during the subsequent oestrous cycle in bitches affected and unaffected by von W illebrand D isease (v WD ); (ii) to correlate the vWF levels and cortisol levels in both groups. Seven v WD affected ( GI ) and nine unaffected ( GII ) bitches were used. The animals were assessed during pregnancy, parturition, lactation and non‐gestational oestrous cycle in 11 moments (Pregnancy 1, Pregnancy 2, Parturition, Lactation 1, Lactation 2, Lactation 3, Anestrus, Proestrus, Oestrus, Diestrus 1, and Diestrus 2). The following tests were performed; measurement of von W illebrand factor antigen (v WF : A g), albumin and cortisol. In both groups, v WF concentration remained stable during the non‐gestational oestrous cycle, but increased during pregnancy, with the highest value observed at parturition. Increases of 70% and 124% in v WF were seen in GI and GII , respectively, compared to anestrus. No correlation was found between v WF and cortisol. Values of v WF : A g changed during pregnancy, with a peak at parturition, both in v WD affected and unaffected animals. Values of v WF were not altered in the different phases of the oestrous cycle following pregnancy in both groups. Evaluation of v WF during pregnancy can cause false negative results for v WD , but assessment can be performed at any point in the oestrous cycle of non‐pregnant bitches." @default.
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• W2042155386 date "2012-10-04" @default.
• W2042155386 modified "2023-10-15" @default.
• W2042155386 title "Evaluation of von Willebrand Factor During Pregnancy, Lactation and Oestrous Cycle in Bitches Affected and Unaffected by von Willebrand Disease" @default.
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• W2042155386 doi "https://doi.org/10.1111/rda.12089" @default.
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