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- W2042164017 abstract "Two new proanthocyanidins, epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin (1) and epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin-3-O-gallate (2) in addition to the known compound epigallocatechin-(4beta-->6)-epigallocatechin-3-O-gallate (3), were isolated from the air-dried herb of Cistus salvifolius. The chemical structures were determined on the basis of 1D-and 2D-NMR-spectra (HSQC, HMBC) of their peracetylated derivatives, MALDI-TOF-mass spectra, and by acid-catalysed degradation with phloroglucinol. The isolated compounds 1-3 and the water extract of C. salvifolius herb were tested for their inhibitory activities against COX-1 and COX-2. Compound 2 showed the strongest inhibitory effect on COX-2 followed by compound 3, compound 1 and the water extract, while compounds 1-3 exhibited moderate in vitro inhibition against COX-1." @default.
- W2042164017 created "2016-06-24" @default.
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- W2042164017 date "2011-08-11" @default.
- W2042164017 modified "2023-09-26" @default.
- W2042164017 title "ChemInform Abstract: Isolation of Two New Bioactive Proanthocyanidins from Cistus salvifolius Herb Extract" @default.
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- W2042164017 doi "https://doi.org/10.1002/chin.201136200" @default.
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