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• W2042165715 abstract "If we could return the planet to ancestral conditions, asked the late Stephen Jay Gould, would we get a replay of the same evolutionary movie? Focusing on the simpler case of nematode domestication, McGrath et al. find that two Caenorhabditis elegans lines and Caenorhabditis briggsae, a species separated by some 20 million years from C. elegans, independently accumulated mutations in a conserved set of pheromone receptor genes, thus reducing the worms' natural trend to hibernate in overcrowded conditions. Such convergence in the adaptation process shows that evolution can indeed be quite reproducible, at least under some specific environmental constraints. Evolution can follow predictable genetic trajectories1, indicating that discrete environmental shifts can select for reproducible genetic changes2,3,4. Conspecific individuals are an important feature of an animal’s environment, and a potential source of selective pressures. Here we show that adaptation of two Caenorhabditis species to growth at high density, a feature common to domestic environments, occurs by reproducible genetic changes to pheromone receptor genes. Chemical communication through pheromones that accumulate during high-density growth causes young nematode larvae to enter the long-lived but non-reproductive dauer stage. Two strains of Caenorhabditis elegans grown at high density have independently acquired multigenic resistance to pheromone-induced dauer formation. In each strain, resistance to the pheromone ascaroside C3 results from a deletion that disrupts the adjacent chemoreceptor genes serpentine receptor class g (srg)-36 and -37. Through misexpression experiments, we show that these genes encode redundant G-protein-coupled receptors for ascaroside C3. Multigenic resistance to dauer formation has also arisen in high-density cultures of a different nematode species, Caenorhabditis briggsae, resulting in part from deletion of an srg gene paralogous to srg-36 and srg-37. These results demonstrate rapid remodelling of the chemoreceptor repertoire as an adaptation to specific environments, and indicate that parallel changes to a common genetic substrate can affect life-history traits across species." @default.
• W2042165715 created "2016-06-24" @default.
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• W2042165715 date "2011-08-17" @default.
• W2042165715 modified "2023-10-05" @default.
• W2042165715 title "Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes" @default.
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• W2042165715 doi "https://doi.org/10.1038/nature10378" @default.
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