FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042176721> ?p ?o ?g. }

• W2042176721 endingPage "e96091" @default.
• W2042176721 startingPage "e96091" @default.
• W2042176721 abstract "Allergic asthma is a lifelong airway condition that affects people of all ages. In recent decades, asthma prevalence continues to increase globally, with an estimated number of 250,000 annual deaths attributed to the disease. Although inhaled corticosteroids and β-adrenergic receptor agonists are the primary therapeutic avenues that effectively reduce asthma symptoms, profound side effects may occur in patients with long-term treatments. Therefore, development of new therapeutic strategies is needed as alternative or supplement to current asthma treatments. Sesamin is a natural polyphenolic compound with strong anti-oxidative effects. Several studies have reported that sesamin is effective in preventing hypertension, thrombotic tendency, and neuroinflammation. However, it is still unknown whether sesamin can reduce asthma-induced allergic inflammation and airway hyperresponsiveness (AHR). Our study has revealed that sesamin exhibited significant anti-inflammatory effects in ovalbumin (OVA)-induced murine asthma model. We found that treatments with sesamin after OVA sensitization and challenge significantly decreased expression levels of interleukin-4 (IL-4), IL-5, IL-13, and serum IgE. The numbers of total inflammatory cells and eosinophils in BALF were also reduced in the sesamin-treated animals. Histological results demonstrated that sesamin attenuated OVA-induced eosinophil infiltration, airway goblet cell hyperplasia, mucus occlusion, and MUC5AC expression in the lung tissue. Mice administered with sesamin showed limited increases in AHR compared with mice receiving vehicle after OVA challenge. OVA increased phosphorylation levels of IκB-α and nuclear expression levels of NF-κB, both of which were reversed by sesamin treatments. These data indicate that sesamin is effective in treating allergic asthma responses induced by OVA in mice." @default.
• W2042176721 created "2016-06-24" @default.
• W2042176721 creator A5008906602 @default.
• W2042176721 creator A5047406249 @default.
• W2042176721 creator A5048464040 @default.
• W2042176721 creator A5069204862 @default.
• W2042176721 creator A5084175244 @default.
• W2042176721 creator A5084404242 @default.
• W2042176721 date "2014-04-22" @default.
• W2042176721 modified "2023-10-10" @default.
• W2042176721 title "Protective Effects of the Polyphenol Sesamin on Allergen-Induced TH2 Responses and Airway Inflammation in Mice" @default.
• W2042176721 cites W1479733192 @default.
• W2042176721 cites W1496660230 @default.
• W2042176721 cites W1543194037 @default.
• W2042176721 cites W1594535986 @default.
• W2042176721 cites W1679882910 @default.
• W2042176721 cites W1877755747 @default.
• W2042176721 cites W1964404485 @default.
• W2042176721 cites W1964952272 @default.
• W2042176721 cites W1970648068 @default.
• W2042176721 cites W1975696541 @default.
• W2042176721 cites W1983805610 @default.
• W2042176721 cites W1993639138 @default.
• W2042176721 cites W1996385800 @default.
• W2042176721 cites W2001465291 @default.
• W2042176721 cites W2001951292 @default.
• W2042176721 cites W2007589345 @default.
• W2042176721 cites W2008364062 @default.
• W2042176721 cites W2012716588 @default.
• W2042176721 cites W2013377406 @default.
• W2042176721 cites W2015649393 @default.
• W2042176721 cites W2016859503 @default.
• W2042176721 cites W2017216596 @default.
• W2042176721 cites W2021701428 @default.
• W2042176721 cites W2028375045 @default.
• W2042176721 cites W2032212448 @default.
• W2042176721 cites W2039859072 @default.
• W2042176721 cites W2040640809 @default.
• W2042176721 cites W2042580565 @default.
• W2042176721 cites W2053798956 @default.
• W2042176721 cites W2055679906 @default.
• W2042176721 cites W2057335633 @default.
• W2042176721 cites W2065541102 @default.
• W2042176721 cites W2067489401 @default.
• W2042176721 cites W2076542859 @default.
• W2042176721 cites W2078363793 @default.
• W2042176721 cites W2089621419 @default.
• W2042176721 cites W2090146653 @default.
• W2042176721 cites W2092535070 @default.
• W2042176721 cites W2094236050 @default.
• W2042176721 cites W2094739393 @default.
• W2042176721 cites W2095164381 @default.
• W2042176721 cites W2095655618 @default.
• W2042176721 cites W2099724264 @default.
• W2042176721 cites W2106598091 @default.
• W2042176721 cites W2107458343 @default.
• W2042176721 cites W2120184224 @default.
• W2042176721 cites W2123641804 @default.
• W2042176721 cites W2124566107 @default.
• W2042176721 cites W2125805192 @default.
• W2042176721 cites W2127154896 @default.
• W2042176721 cites W2135003275 @default.
• W2042176721 cites W2140942460 @default.
• W2042176721 cites W2141585732 @default.
• W2042176721 cites W2150735893 @default.
• W2042176721 cites W2152814087 @default.
• W2042176721 cites W2153499793 @default.
• W2042176721 cites W2154100077 @default.
• W2042176721 cites W2154159315 @default.
• W2042176721 cites W2156115651 @default.
• W2042176721 cites W2160287057 @default.
• W2042176721 cites W4230976467 @default.
• W2042176721 cites W4254570903 @default.
• W2042176721 doi "https://doi.org/10.1371/journal.pone.0096091" @default.
• W2042176721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3996011" @default.
• W2042176721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24755955" @default.
• W2042176721 hasPublicationYear "2014" @default.
• W2042176721 type Work @default.
• W2042176721 sameAs 2042176721 @default.
• W2042176721 citedByCount "26" @default.
• W2042176721 countsByYear W20421767212014 @default.
• W2042176721 countsByYear W20421767212015 @default.
• W2042176721 countsByYear W20421767212016 @default.
• W2042176721 countsByYear W20421767212017 @default.
• W2042176721 countsByYear W20421767212018 @default.
• W2042176721 countsByYear W20421767212019 @default.
• W2042176721 countsByYear W20421767212020 @default.
• W2042176721 countsByYear W20421767212021 @default.
• W2042176721 countsByYear W20421767212022 @default.
• W2042176721 countsByYear W20421767212023 @default.
• W2042176721 crossrefType "journal-article" @default.
• W2042176721 hasAuthorship W2042176721A5008906602 @default.
• W2042176721 hasAuthorship W2042176721A5047406249 @default.
• W2042176721 hasAuthorship W2042176721A5048464040 @default.
• W2042176721 hasAuthorship W2042176721A5069204862 @default.
• W2042176721 hasAuthorship W2042176721A5084175244 @default.
• W2042176721 hasAuthorship W2042176721A5084404242 @default.
• W2042176721 hasBestOaLocation W20421767211 @default.

• next