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- W2042177580 abstract "This article suggests a unified framework for testing Proof of Concept (PoC) and estimating a target dose for the benefit of a more comprehensive, robust and powerful analysis in phase II or similar clinical trials. From a pre-specified set of candidate models, we choose the ones that best describe the observed dose–response. To decide which models, if any, significantly pick up a dose effect, we construct the permutation distribution of the minimum P-value over the candidate set. This allows us to find critical values and multiplicity adjusted P-values that control the familywise error rate of declaring any spurious effect in the candidate set as significant. Model averaging is then used to estimate a target dose. Popular single or multiple contrast tests for PoC, such as the Cochran–Armitage, Dunnett or Williams tests, are only optimal for specific dose–response shapes and do not provide target dose estimates with confidence limits. A thorough evaluation and comparison of our approach to these tests reveal that its power is as good or better in detecting a dose–response under various shapes with many more additional benefits: It incorporates model uncertainty in PoC decisions and target dose estimation, yields confidence intervals for target dose estimates and extends to more complicated data structures. We illustrate our method with the analysis of a Phase II clinical trial. Copyright © 2008 John Wiley & Sons, Ltd." @default.
- W2042177580 created "2016-06-24" @default.
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- W2042177580 date "2008-11-14" @default.
- W2042177580 modified "2023-09-23" @default.
- W2042177580 title "Proof of concept and dose estimation with binary responses under model uncertainty" @default.
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- W2042177580 doi "https://doi.org/10.1002/sim.3477" @default.
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