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- W2042179499 abstract "Dosing recommendations for vancomycin, which has primarily renal elimination, are derived from studies demonstrating that renal function in the human neonate increases significantly at approximately 34 wks postconceptional age(PCA, where PCA = gestational age[GA] + PNA). To examine the independent role of PNA, we calculated vancomycin pharmacokinetics (104 studies) in 79 critically-ill neonates. Elimination rate constant (Kel) and volume of distribution (Vd) were determined. As shown in the Table(mean±SD), infants were divided into three GA groups: ≤30, 31-35, and >35 wks(PCA 31.3±3.2, 35.9±3.9, and 42.8±2.0 wks, respectively). Although Kel was greater in the more mature infants, a significant correlation between PNA and Kel was observed within each gestational age group. Furthermore, for all infants with PCA 29-36 wks, the correlation between PNA and Kel was r=.49, p 35 wks)" @default.
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- W2042179499 date "1997-04-01" @default.
- W2042179499 modified "2023-09-27" @default.
- W2042179499 title "Importance of Postnatal Age(PNA) in Vancomycin Pharmacokinetics in the Critically-ill Neonate. 317" @default.
- W2042179499 doi "https://doi.org/10.1203/00006450-199704001-00337" @default.
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