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- W2042179780 abstract "Recent data from transgenic mice suggest that orexin plays an important role in the ventilatory response to CO 2 during wakefulness. We hypothesized that orexin receptor‐1 (OX 1 R) in the retrotrapezoid nucleus (RTN) contributes to chemoreception. In unanaesthetized rats, we measured ventilation using a whole‐body plethysmograph, together with EEG and EMG. We dialysed the vehicle and then SB‐334867 (OX 1 R antagonist) into the RTN to focally inhibit OX 1 R and studied the effects of both treatments on breathing in air and in 7% CO 2 . During wakefulness, SB‐334867 caused a 30% reduction of the hyperventilation induced by 7% CO 2 (mean ± S.E.M., 135 ± 10 ml (100 g) −1 min −1 ) compared with vehicle (182 ± 10 ml (100 g) −1 min −1 ) ( P < 0.01). This effect was due to both decreased tidal volume and breathing frequency. There was a much smaller, though significant, effect in sleep (9% reduction). Neither basal ventilation nor oxygen consumption was affected. The number and duration of apnoeas were similar between control and treatment periods. No effect was observed in a separate group of animals who had the microdialysis probe misplaced (peri‐RTN). We conclude that projections of orexin‐containing neurons to the RTN contribute, via OX 1 Rs in the region, to the hypercapnic chemoreflex control during wakefulness and to a lesser extent, non‐rapid eye movement sleep." @default.
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- W2042179780 date "2009-04-29" @default.
- W2042179780 modified "2023-10-18" @default.
- W2042179780 title "Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness" @default.
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- W2042179780 doi "https://doi.org/10.1113/jphysiol.2008.168260" @default.
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