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• W2042179919 endingPage "677" @default.
• W2042179919 startingPage "667" @default.
• W2042179919 abstract "A limitation in the administration of parenteral products is the pain caused upon injection. Injection site pain has been predominately associated with intravenous, intramuscular, and subcutaneous administration. It becomes important for the formulation scientist to have a basic understanding of the physiology underlying the pain process, as well as the pharmaceutical factors associated with injection site pain. Initially, this review will provide the reader with a primer on the mediation of pain in the periphery and a compilation of those drugs that have been associated with pain on injection. In addition, this review will present important considerations and general formulation approaches or methods that have been used to overcome pain on injection. Finally, a brief overview of the various experimental systems used to investigate injection site pain is discussed." @default.
• W2042179919 created "2016-06-24" @default.
• W2042179919 creator A5018720638 @default.
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• W2042179919 creator A5049614203 @default.
• W2042179919 creator A5054494090 @default.
• W2042179919 creator A5062016300 @default.
• W2042179919 date "1998-06-01" @default.
• W2042179919 modified "2023-09-23" @default.
• W2042179919 title "Current Perspectives on Pain upon Injection of Drugs" @default.
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• W2042179919 doi "https://doi.org/10.1021/js970315l" @default.
• W2042179919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9607942" @default.
• W2042179919 hasPublicationYear "1998" @default.
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