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• W2042181818 endingPage "152" @default.
• W2042181818 startingPage "142" @default.
• W2042181818 abstract "The nature of progesterone (P4)'s neuroprotective effects is of interest. We investigated effects of P4 when administered before, or after, kainic acid, which produces ictal activity and damage to the hippocampus, to mediate effects on spatial performance. The hypothesis was that P4, compared with vehicle, would reduce decrements in Morris Water Maze performance induced by kainic acid. Experiment 1: We examined the effects of kainic acid on plasma stress hormone, corticosterone, and progestogen (P4 and its metabolites) levels in plasma and the hippocampus after subcutaneous (s.c.) P4 administration to ovariectomized rats. Rats administered kainic acid had the highest corticosterone levels immediately following injection. P4 is 5α-reduced to dihydroprogesterone (DHP) and subsequently metabolized to 5α-pregnan-3α-ol-20-one (3α,5α-THP) by 3α-hydroxysteroid dehydrogenase. The regimen of P4 used produced circulating and hippocampal levels of P4, DHP, and 3α,5α-THP within a physiological range, which declined at 14 hours postinjection and were not altered by kainic acid. Experiment 2: The physiological P4 regimen was administered to rats before, or after, kainic acid-induced seizures, and later effects on water maze performance were compared with that of rats administered vehicle. Rats administered kainic acid had significantly poorer performance in the water maze (i.e., increased latencies and distances to the hidden platform) than did rats administered vehicle. Administration of P4 before, but not after, kainic acid prevented these performance deficits. Thus, these data suggest that a physiological regimen of P4 can prevent some of the deficits in water maze performance produced by kainic acid. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 142-152, 2011" @default.
• W2042181818 created "2016-06-24" @default.
• W2042181818 creator A5009051197 @default.
• W2042181818 creator A5077485513 @default.
• W2042181818 date "2011-01-07" @default.
• W2042181818 modified "2023-09-25" @default.
• W2042181818 title "Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze" @default.
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• W2042181818 doi "https://doi.org/10.1002/dneu.20832" @default.
• W2042181818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3546536" @default.
• W2042181818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20715152" @default.
• W2042181818 hasPublicationYear "2011" @default.
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