FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042182570> ?p ?o ?g. }

• W2042182570 abstract "The influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor consisting of an RNA binding domain and several Src-homology (SH) 2 and SH3 binding motifs, which promotes virus replication in the host cell and helps to evade antiviral immunity. NS1 modulates general host cell physiology in association with various cellular molecules including NS1-binding protein (NS1-BP) and signaling adapter protein CRK-like (CRKL), while the physiological role of NS1-BP during influenza A virus infection especially in association with NS1 remains unclear. In this study, we analyzed the intracellular association of NS1-BP, NS1 and CRKL to elucidate the physiological roles of these molecules in the host cell. In HEK293T cells, enforced expression of NS1 of A/Beijing (H1N1) and A/Indonesia (H5N1) significantly induced excessive phosphorylation of ERK and elevated cell viability, while the over-expression of NS1-BP and the abrogation of CRKL using siRNA abolished such survival effect of NS1. The pull-down assay using GST-fusion CRKL revealed the formation of intracellular complexes of NS1-BP, NS1 and CRKL. In addition, we identified that the N-terminus SH3 domain of CRKL was essential for binding to NS1-BP using GST-fusion CRKL-truncate mutants. This is the first report to elucidate the novel function of NS1-BP collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated." @default.
• W2042182570 created "2016-06-24" @default.
• W2042182570 creator A5011353339 @default.
• W2042182570 creator A5015581986 @default.
• W2042182570 creator A5016393442 @default.
• W2042182570 creator A5026930275 @default.
• W2042182570 creator A5028907649 @default.
• W2042182570 creator A5054053950 @default.
• W2042182570 creator A5057784648 @default.
• W2042182570 creator A5073216396 @default.
• W2042182570 creator A5082452145 @default.
• W2042182570 date "2013-11-01" @default.
• W2042182570 modified "2023-09-27" @default.
• W2042182570 title "NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL" @default.
• W2042182570 cites W1505648210 @default.
• W2042182570 cites W1531461972 @default.
• W2042182570 cites W158709665 @default.
• W2042182570 cites W1832989418 @default.
• W2042182570 cites W1928398558 @default.
• W2042182570 cites W1963932113 @default.
• W2042182570 cites W1975729134 @default.
• W2042182570 cites W1976918795 @default.
• W2042182570 cites W1999542797 @default.
• W2042182570 cites W2013463232 @default.
• W2042182570 cites W2015298999 @default.
• W2042182570 cites W2018234381 @default.
• W2042182570 cites W2018248223 @default.
• W2042182570 cites W2023035638 @default.
• W2042182570 cites W2026853987 @default.
• W2042182570 cites W2029349801 @default.
• W2042182570 cites W2049885346 @default.
• W2042182570 cites W2055380229 @default.
• W2042182570 cites W2056165940 @default.
• W2042182570 cites W2061032348 @default.
• W2042182570 cites W2070174475 @default.
• W2042182570 cites W2084978375 @default.
• W2042182570 cites W2097317987 @default.
• W2042182570 cites W2110214166 @default.
• W2042182570 cites W2113001027 @default.
• W2042182570 cites W2113875632 @default.
• W2042182570 cites W2123070759 @default.
• W2042182570 cites W2139463994 @default.
• W2042182570 cites W2142203996 @default.
• W2042182570 cites W2150658610 @default.
• W2042182570 cites W2160898409 @default.
• W2042182570 cites W2314654345 @default.
• W2042182570 cites W2416976408 @default.
• W2042182570 doi "https://doi.org/10.1016/j.bbrc.2013.11.011" @default.
• W2042182570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24220336" @default.
• W2042182570 hasPublicationYear "2013" @default.
• W2042182570 type Work @default.
• W2042182570 sameAs 2042182570 @default.
• W2042182570 citedByCount "10" @default.
• W2042182570 countsByYear W20421825702014 @default.
• W2042182570 countsByYear W20421825702015 @default.
• W2042182570 countsByYear W20421825702017 @default.
• W2042182570 countsByYear W20421825702018 @default.
• W2042182570 countsByYear W20421825702020 @default.
• W2042182570 countsByYear W20421825702021 @default.
• W2042182570 countsByYear W20421825702022 @default.
• W2042182570 crossrefType "journal-article" @default.
• W2042182570 hasAuthorship W2042182570A5011353339 @default.
• W2042182570 hasAuthorship W2042182570A5015581986 @default.
• W2042182570 hasAuthorship W2042182570A5016393442 @default.
• W2042182570 hasAuthorship W2042182570A5026930275 @default.
• W2042182570 hasAuthorship W2042182570A5028907649 @default.
• W2042182570 hasAuthorship W2042182570A5054053950 @default.
• W2042182570 hasAuthorship W2042182570A5057784648 @default.
• W2042182570 hasAuthorship W2042182570A5073216396 @default.
• W2042182570 hasAuthorship W2042182570A5082452145 @default.
• W2042182570 hasBestOaLocation W20421825702 @default.
• W2042182570 hasConcept C104317684 @default.
• W2042182570 hasConcept C108636557 @default.
• W2042182570 hasConcept C123894998 @default.
• W2042182570 hasConcept C159047783 @default.
• W2042182570 hasConcept C183786373 @default.
• W2042182570 hasConcept C185592680 @default.
• W2042182570 hasConcept C196347352 @default.
• W2042182570 hasConcept C2522874641 @default.
• W2042182570 hasConcept C2777546802 @default.
• W2042182570 hasConcept C40767141 @default.
• W2042182570 hasConcept C55493867 @default.
• W2042182570 hasConcept C62478195 @default.
• W2042182570 hasConcept C86803240 @default.
• W2042182570 hasConcept C95444343 @default.
• W2042182570 hasConceptScore W2042182570C104317684 @default.
• W2042182570 hasConceptScore W2042182570C108636557 @default.
• W2042182570 hasConceptScore W2042182570C123894998 @default.
• W2042182570 hasConceptScore W2042182570C159047783 @default.
• W2042182570 hasConceptScore W2042182570C183786373 @default.
• W2042182570 hasConceptScore W2042182570C185592680 @default.
• W2042182570 hasConceptScore W2042182570C196347352 @default.
• W2042182570 hasConceptScore W2042182570C2522874641 @default.
• W2042182570 hasConceptScore W2042182570C2777546802 @default.
• W2042182570 hasConceptScore W2042182570C40767141 @default.
• W2042182570 hasConceptScore W2042182570C55493867 @default.
• W2042182570 hasConceptScore W2042182570C62478195 @default.
• W2042182570 hasConceptScore W2042182570C86803240 @default.
• W2042182570 hasConceptScore W2042182570C95444343 @default.
• W2042182570 hasLocation W20421825701 @default.

• next