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• W2042184438 endingPage "e0119776" @default.
• W2042184438 startingPage "e0119776" @default.
• W2042184438 abstract "Background Acute lymphoblastic leukemia (ALL) is the most prevalent type of pediatric cancer, the causes of which are likely to involve an interaction between genetic and environmental factors. To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations. Methodology/Principal Findings In total, 266 patients with childhood ALL and an equal number of non-cancer controls recruited were genotyped utilizing PCR-RFLP methodology. The MTHFR C677T genotype, but not the A1298C, was differently distributed between childhood ALL and control groups. The CT and TT of MTHFR C677T genotypes were significantly more frequently found in controls than in childhood ALL patients (odds ratios=0.60 and 0.48, 95% confidence intervals=0.42–0.87 and 0.24–0.97, respectively). As for gender, the boys carrying the MTHFR C677T CT or TT genotype conferred a lower odds ratio of 0.51 (95% confidence interval=0.32–0.81, P=0.0113) for childhood ALL. As for age, those equal to or greater than 3.5 years of age at onset of disease carrying the MTHFR C677T CT or TT genotype were of lower risk (odds ratio= 0.43 and 95% confidence interval=0.26–0.71, P=0.0016). Conclusions Our results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease." @default.
• W2042184438 created "2016-06-24" @default.
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• W2042184438 date "2015-03-20" @default.
• W2042184438 modified "2023-10-18" @default.
• W2042184438 title "The Association of Methylenetetrahydrofolate Reductase Genotypes with the Risk of Childhood Leukemia in Taiwan" @default.
• W2042184438 cites W1482397881 @default.
• W2042184438 cites W1763462857 @default.
• W2042184438 cites W1944648626 @default.
• W2042184438 cites W1964687425 @default.
• W2042184438 cites W1969385690 @default.
• W2042184438 cites W1974520981 @default.
• W2042184438 cites W1976629892 @default.
• W2042184438 cites W1977641772 @default.
• W2042184438 cites W1979426291 @default.
• W2042184438 cites W1982002673 @default.
• W2042184438 cites W1991592806 @default.
• W2042184438 cites W1998001279 @default.
• W2042184438 cites W2005228342 @default.
• W2042184438 cites W2016799269 @default.
• W2042184438 cites W2021350807 @default.
• W2042184438 cites W2024558578 @default.
• W2042184438 cites W2025498967 @default.
• W2042184438 cites W2030504292 @default.
• W2042184438 cites W2030886447 @default.
• W2042184438 cites W2031262735 @default.
• W2042184438 cites W2035735532 @default.
• W2042184438 cites W2040052168 @default.
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• W2042184438 cites W2065340429 @default.
• W2042184438 cites W2068646871 @default.
• W2042184438 cites W2069107284 @default.
• W2042184438 cites W2071244728 @default.
• W2042184438 cites W2072277211 @default.
• W2042184438 cites W2075655900 @default.
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• W2042184438 cites W2078154562 @default.
• W2042184438 cites W2079731735 @default.
• W2042184438 cites W2083838268 @default.
• W2042184438 cites W2103274613 @default.
• W2042184438 cites W2103464247 @default.
• W2042184438 cites W2104004482 @default.
• W2042184438 cites W2104104582 @default.
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• W2042184438 cites W2116264394 @default.
• W2042184438 cites W2120854518 @default.
• W2042184438 cites W2121563888 @default.
• W2042184438 cites W2128561460 @default.
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• W2042184438 cites W2144500318 @default.
• W2042184438 cites W2144741882 @default.
• W2042184438 cites W2144891453 @default.
• W2042184438 cites W2148090392 @default.
• W2042184438 cites W2149384322 @default.
• W2042184438 cites W2155395660 @default.
• W2042184438 cites W2158091821 @default.
• W2042184438 cites W2158462600 @default.
• W2042184438 cites W2158891251 @default.
• W2042184438 cites W2161927091 @default.
• W2042184438 cites W2169000172 @default.
• W2042184438 cites W2169579710 @default.
• W2042184438 cites W2170535301 @default.
• W2042184438 cites W2189253330 @default.
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• W2042184438 doi "https://doi.org/10.1371/journal.pone.0119776" @default.
• W2042184438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4368437" @default.
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• W2042184438 hasPublicationYear "2015" @default.
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