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• W2042185807 startingPage "BR469" @default.
• W2042185807 abstract "Background:An elevated serum concentration of homocysteine (hyperhomocysteinemia) has been shown to disturb fracture healing. As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair.Material/Methods:We analyzed bone repair in 2 groups of mice. One group was fed a methionine-rich diet (n=13), and the second group received an equicaloric control diet without methionine supplementation (n=12). Using a closed femoral fracture model, bone repair was analyzed by histomorphometry and biomechanical testing at 4 weeks after fracture. Blood was sampled to measure serum concentrations of homocysteine, the bone formation marker osteocalcin, and the bone resorption marker collagen I C-terminal crosslapsResults:Serum concentrations of homocysteine were significantly higher in the methionine group than in the control group, while serum markers of bone turnover did not differ significantly between the 2 groups. Histomorphometry revealed no significant differences in size and tissue composition of the callus between animals fed the methionine-enriched diet and those receiving the control diet. Accordingly, animals of the 2 groups showed a comparable bending stiffness of the healing bones.Conclusions:We conclude that excess methionine intake causes hyperhomocysteinemia, but does not affect fracture healing in mice." @default.
• W2042185807 created "2016-06-24" @default.
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• W2042185807 date "2012-01-01" @default.
• W2042185807 modified "2023-10-16" @default.
• W2042185807 title "Excess dietary methionine does not affect fracture healing in mice" @default.
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• W2042185807 doi "https://doi.org/10.12659/msm.883590" @default.
• W2042185807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560796" @default.
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