FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042186925> ?p ?o ?g. }

• W2042186925 endingPage "5800" @default.
• W2042186925 startingPage "5793" @default.
• W2042186925 abstract "To decipher the clues of genotype-phenotype mapping in androgen insensitivity syndromes (AIS), we integrated clinical, molecular, and structural data in an investigation into the characteristics of androgen receptor (AR) ligand binding and activation. We looked for residues substituted in AIS that are conserved among the different AR species but that diverge in the other steroid receptors, thus suggesting a role in androgen binding specificity. Of the residues fitting these characteristics, we focused on the glycine at position 743, for which natural substitutions (glutamic acid and valine) have been associated with different androgen resistance phenotypes. The consequences of both substitutions were evaluated along with the minimal glycine to alanine mutation. The gradual impairment of binding and trans-activation efficiencies in AR mutants ranging from alanine to valine and subsequently glutamic acid were highlighted by in vitro experiments. Structural analyses showed the consequences of these substitutions at the atomic level and suggested a difference in local organization among the nuclear receptor superfamily. Overall, this integrative approach provides a useful tool for further investigations into the AR structure-function relationship in AIS." @default.
• W2042186925 created "2016-06-24" @default.
• W2042186925 creator A5030536306 @default.
• W2042186925 creator A5031632319 @default.
• W2042186925 creator A5045707650 @default.
• W2042186925 creator A5072309182 @default.
• W2042186925 creator A5087324619 @default.
• W2042186925 creator A5006829407 @default.
• W2042186925 date "2002-12-01" @default.
• W2042186925 modified "2023-10-18" @default.
• W2042186925 title "Pathophysiology of Androgen Insensitivity Syndromes: Molecular and Structural Approaches of Natural and Engineered Androgen Receptor Mutations at Amino Acid 743" @default.
• W2042186925 cites W1578094132 @default.
• W2042186925 cites W1907321242 @default.
• W2042186925 cites W1952989898 @default.
• W2042186925 cites W1974081758 @default.
• W2042186925 cites W1982381000 @default.
• W2042186925 cites W1983721081 @default.
• W2042186925 cites W1994885159 @default.
• W2042186925 cites W1995453026 @default.
• W2042186925 cites W1997155817 @default.
• W2042186925 cites W2002032260 @default.
• W2042186925 cites W2006047247 @default.
• W2042186925 cites W2007336029 @default.
• W2042186925 cites W2013083986 @default.
• W2042186925 cites W2021118932 @default.
• W2042186925 cites W2021719977 @default.
• W2042186925 cites W2049521571 @default.
• W2042186925 cites W2051560563 @default.
• W2042186925 cites W2061686178 @default.
• W2042186925 cites W2076314091 @default.
• W2042186925 cites W2077854579 @default.
• W2042186925 cites W2084639732 @default.
• W2042186925 cites W2084829629 @default.
• W2042186925 cites W2092239168 @default.
• W2042186925 cites W2097374228 @default.
• W2042186925 cites W2101738855 @default.
• W2042186925 cites W2111452151 @default.
• W2042186925 cites W2111650618 @default.
• W2042186925 cites W2116474322 @default.
• W2042186925 cites W2141745081 @default.
• W2042186925 cites W2144908726 @default.
• W2042186925 cites W2151922331 @default.
• W2042186925 cites W2160534562 @default.
• W2042186925 cites W2163839067 @default.
• W2042186925 cites W2172256092 @default.
• W2042186925 cites W2408914779 @default.
• W2042186925 doi "https://doi.org/10.1210/jc.2002-020491" @default.
• W2042186925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466388" @default.
• W2042186925 hasPublicationYear "2002" @default.
• W2042186925 type Work @default.
• W2042186925 sameAs 2042186925 @default.
• W2042186925 citedByCount "14" @default.
• W2042186925 countsByYear W20421869252014 @default.
• W2042186925 countsByYear W20421869252015 @default.
• W2042186925 countsByYear W20421869252016 @default.
• W2042186925 countsByYear W20421869252018 @default.
• W2042186925 countsByYear W20421869252020 @default.
• W2042186925 countsByYear W20421869252023 @default.
• W2042186925 crossrefType "journal-article" @default.
• W2042186925 hasAuthorship W2042186925A5006829407 @default.
• W2042186925 hasAuthorship W2042186925A5030536306 @default.
• W2042186925 hasAuthorship W2042186925A5031632319 @default.
• W2042186925 hasAuthorship W2042186925A5045707650 @default.
• W2042186925 hasAuthorship W2042186925A5072309182 @default.
• W2042186925 hasAuthorship W2042186925A5087324619 @default.
• W2042186925 hasConcept C104317684 @default.
• W2042186925 hasConcept C121608353 @default.
• W2042186925 hasConcept C126322002 @default.
• W2042186925 hasConcept C127716648 @default.
• W2042186925 hasConcept C134018914 @default.
• W2042186925 hasConcept C170493617 @default.
• W2042186925 hasConcept C2777573094 @default.
• W2042186925 hasConcept C2777911890 @default.
• W2042186925 hasConcept C2778952551 @default.
• W2042186925 hasConcept C2779856020 @default.
• W2042186925 hasConcept C2780192828 @default.
• W2042186925 hasConcept C501734568 @default.
• W2042186925 hasConcept C515207424 @default.
• W2042186925 hasConcept C54355233 @default.
• W2042186925 hasConcept C55493867 @default.
• W2042186925 hasConcept C61367390 @default.
• W2042186925 hasConcept C63932345 @default.
• W2042186925 hasConcept C71315377 @default.
• W2042186925 hasConcept C71924100 @default.
• W2042186925 hasConcept C86339819 @default.
• W2042186925 hasConcept C86803240 @default.
• W2042186925 hasConceptScore W2042186925C104317684 @default.
• W2042186925 hasConceptScore W2042186925C121608353 @default.
• W2042186925 hasConceptScore W2042186925C126322002 @default.
• W2042186925 hasConceptScore W2042186925C127716648 @default.
• W2042186925 hasConceptScore W2042186925C134018914 @default.
• W2042186925 hasConceptScore W2042186925C170493617 @default.
• W2042186925 hasConceptScore W2042186925C2777573094 @default.
• W2042186925 hasConceptScore W2042186925C2777911890 @default.
• W2042186925 hasConceptScore W2042186925C2778952551 @default.
• W2042186925 hasConceptScore W2042186925C2779856020 @default.
• W2042186925 hasConceptScore W2042186925C2780192828 @default.
• W2042186925 hasConceptScore W2042186925C501734568 @default.

• next