Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042188116> ?p ?o ?g. }
- W2042188116 endingPage "171" @default.
- W2042188116 startingPage "164" @default.
- W2042188116 abstract "Hepatitis C virus (HCV), especially the genotype 1, is naturally resistant to the antiviral effects of interferon-alpha (IFN-α). Expression of the whole HCV genome and the NS5A protein has been suggested to interfere with the antiviral activity of IFN-α. Here we have analyzed the effect of individual or various combinations of HCV proteins on IFN-α-mediated antiviral effect against vesicular stomatitis virus (VSV). When the structural proteins (core-E1-E2) of HCV genotype 1 were expressed in human osteosarcoma cells in a tetracycline-regulated manner, partial VSV resistance to IFN-α was established. This was seen as an enhancement of both viral protein synthesis and production of infectious virus. Priming of core-E1-E2-expressing cells with low doses of IFN-γ (10 IU/ml) partially restored the antiviral activity of IFN-α. The core (high-level expression) and NS4B protein expression also showed some rescue of VSV replication. In this model cell system NS3A–NS4A complex and NS5A showed no inhibition of IFN-α-induced antiviral activity. Our results indicate that the expression of structural proteins of HCV may impair the antiviral activity of IFNs." @default.
- W2042188116 created "2016-06-24" @default.
- W2042188116 creator A5007995979 @default.
- W2042188116 creator A5011996258 @default.
- W2042188116 creator A5012309526 @default.
- W2042188116 date "2002-08-01" @default.
- W2042188116 modified "2023-10-16" @default.
- W2042188116 title "Expression of HCV Structural Proteins Impairs IFN-Mediated Antiviral Response" @default.
- W2042188116 cites W1426432049 @default.
- W2042188116 cites W1670758519 @default.
- W2042188116 cites W1971939843 @default.
- W2042188116 cites W1973165481 @default.
- W2042188116 cites W1984030417 @default.
- W2042188116 cites W1996208605 @default.
- W2042188116 cites W2030277568 @default.
- W2042188116 cites W2037886185 @default.
- W2042188116 cites W2048319398 @default.
- W2042188116 cites W2052014046 @default.
- W2042188116 cites W2052325775 @default.
- W2042188116 cites W2052489625 @default.
- W2042188116 cites W2059280966 @default.
- W2042188116 cites W2059457521 @default.
- W2042188116 cites W2059530064 @default.
- W2042188116 cites W2064807794 @default.
- W2042188116 cites W2067015560 @default.
- W2042188116 cites W2068708349 @default.
- W2042188116 cites W2069633422 @default.
- W2042188116 cites W2073675795 @default.
- W2042188116 cites W2075251791 @default.
- W2042188116 cites W2078937761 @default.
- W2042188116 cites W2079377965 @default.
- W2042188116 cites W2080332962 @default.
- W2042188116 cites W2081676299 @default.
- W2042188116 cites W2092470099 @default.
- W2042188116 cites W2093137226 @default.
- W2042188116 cites W2100837269 @default.
- W2042188116 cites W2103565638 @default.
- W2042188116 cites W2122151579 @default.
- W2042188116 cites W2133929317 @default.
- W2042188116 cites W2139287551 @default.
- W2042188116 cites W2141894346 @default.
- W2042188116 cites W2143613583 @default.
- W2042188116 cites W2158697492 @default.
- W2042188116 cites W2160520953 @default.
- W2042188116 cites W2166086535 @default.
- W2042188116 cites W2168543151 @default.
- W2042188116 cites W2317554121 @default.
- W2042188116 cites W2318639814 @default.
- W2042188116 cites W2341829866 @default.
- W2042188116 doi "https://doi.org/10.1006/viro.2002.1527" @default.
- W2042188116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12202219" @default.
- W2042188116 hasPublicationYear "2002" @default.
- W2042188116 type Work @default.
- W2042188116 sameAs 2042188116 @default.
- W2042188116 citedByCount "21" @default.
- W2042188116 countsByYear W20421881162014 @default.
- W2042188116 countsByYear W20421881162015 @default.
- W2042188116 crossrefType "journal-article" @default.
- W2042188116 hasAuthorship W2042188116A5007995979 @default.
- W2042188116 hasAuthorship W2042188116A5011996258 @default.
- W2042188116 hasAuthorship W2042188116A5012309526 @default.
- W2042188116 hasBestOaLocation W20421881161 @default.
- W2042188116 hasConcept C104317684 @default.
- W2042188116 hasConcept C159047783 @default.
- W2042188116 hasConcept C2522874641 @default.
- W2042188116 hasConcept C2776178377 @default.
- W2042188116 hasConcept C2776408679 @default.
- W2042188116 hasConcept C2776746152 @default.
- W2042188116 hasConcept C2777103181 @default.
- W2042188116 hasConcept C2779057330 @default.
- W2042188116 hasConcept C2781463415 @default.
- W2042188116 hasConcept C55493867 @default.
- W2042188116 hasConcept C67705224 @default.
- W2042188116 hasConcept C86803240 @default.
- W2042188116 hasConceptScore W2042188116C104317684 @default.
- W2042188116 hasConceptScore W2042188116C159047783 @default.
- W2042188116 hasConceptScore W2042188116C2522874641 @default.
- W2042188116 hasConceptScore W2042188116C2776178377 @default.
- W2042188116 hasConceptScore W2042188116C2776408679 @default.
- W2042188116 hasConceptScore W2042188116C2776746152 @default.
- W2042188116 hasConceptScore W2042188116C2777103181 @default.
- W2042188116 hasConceptScore W2042188116C2779057330 @default.
- W2042188116 hasConceptScore W2042188116C2781463415 @default.
- W2042188116 hasConceptScore W2042188116C55493867 @default.
- W2042188116 hasConceptScore W2042188116C67705224 @default.
- W2042188116 hasConceptScore W2042188116C86803240 @default.
- W2042188116 hasIssue "2" @default.
- W2042188116 hasLocation W20421881161 @default.
- W2042188116 hasLocation W20421881162 @default.
- W2042188116 hasOpenAccess W2042188116 @default.
- W2042188116 hasPrimaryLocation W20421881161 @default.
- W2042188116 hasRelatedWork W1605500799 @default.
- W2042188116 hasRelatedWork W1969231455 @default.
- W2042188116 hasRelatedWork W2047828045 @default.
- W2042188116 hasRelatedWork W2085318865 @default.
- W2042188116 hasRelatedWork W2092470099 @default.
- W2042188116 hasRelatedWork W2166086535 @default.
- W2042188116 hasRelatedWork W2393387431 @default.