Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042196624> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2042196624 endingPage "2085" @default.
- W2042196624 startingPage "2081" @default.
- W2042196624 abstract "The expression of nitric oxide synthase (NOS) was studied by NAD(P)H diaphorase histochemical localization method in (i) individual cells of the normal colonic mucosa (n = 13) which served as control, (ii) colonic polyps (n = 14), (iii) colonic carcinoma (n = 20) and (iv) peritumoral mucosa (2 and 5 or 10 cm away from the tumor). Four of the tumor specimens had normal epithelium adjacent to the cancer, which thus served as an internal control. The expression of NOS activity in colon cancer was significantly reduced as compared to the control group of individuals (P < 0.004); undetectable in 25%, diminished in 45%, normal in 30%. On comparing the expression in normal mucosa and polyps there was a significant reduction of the expression in polyps (P < 0.027); undetectable in 14%, reduced in 35%, normal in 51%. When compared to the peritumoral mucosa at 2 and 10 cm the tumor showed a significant reduction in expression of NOS activity (P < 0.001 and P < 0.0001 respectively). There was no significant difference seen in the expression at 2 and 10 cm (P = 0.329). The peritumoral mucosa at a distance of 2 cm away from the tumor when compared to the control mucosa showed no significant difference (P = 1.000), although there is a tendency to a high normal expression of NOS activity in the mucosa at a distance of 2 cm. Similarly, there was no significant difference between the control mucosa and the peritumoral mucosa obtained at a distance of 10 cm (P = 0.383). The expression of NOS activity in all tissues examined was abolished by preincubation of tissue with the selective NOS inhibitor L-NMMA but not with D-NMMA. Our data showed extensive and significant reduction as identified by the NAD(P)H diaphorase method in the expression of NOS activity, thereby reflecting the activity of nitric oxide in colon cancer and colonic polyps. The generalized suppression of this activity, which precedes the onset of overt neoplasia, may be an important event in colon carcinogenesis. This aberrant expression could also be compatible with the selective advantage to either tumor promotion and metastatic progression or to tumoricidal activity." @default.
- W2042196624 created "2016-06-24" @default.
- W2042196624 creator A5003510876 @default.
- W2042196624 creator A5014693062 @default.
- W2042196624 creator A5016601328 @default.
- W2042196624 creator A5018812816 @default.
- W2042196624 creator A5086683514 @default.
- W2042196624 date "1994-01-01" @default.
- W2042196624 modified "2023-09-30" @default.
- W2042196624 title "Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa" @default.
- W2042196624 doi "https://doi.org/10.1093/carcin/15.10.2081" @default.
- W2042196624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7525094" @default.
- W2042196624 hasPublicationYear "1994" @default.
- W2042196624 type Work @default.
- W2042196624 sameAs 2042196624 @default.
- W2042196624 citedByCount "73" @default.
- W2042196624 countsByYear W20421966242012 @default.
- W2042196624 countsByYear W20421966242013 @default.
- W2042196624 countsByYear W20421966242014 @default.
- W2042196624 countsByYear W20421966242015 @default.
- W2042196624 countsByYear W20421966242018 @default.
- W2042196624 countsByYear W20421966242021 @default.
- W2042196624 countsByYear W20421966242023 @default.
- W2042196624 crossrefType "journal-article" @default.
- W2042196624 hasAuthorship W2042196624A5003510876 @default.
- W2042196624 hasAuthorship W2042196624A5014693062 @default.
- W2042196624 hasAuthorship W2042196624A5016601328 @default.
- W2042196624 hasAuthorship W2042196624A5018812816 @default.
- W2042196624 hasAuthorship W2042196624A5086683514 @default.
- W2042196624 hasConcept C126322002 @default.
- W2042196624 hasConcept C142724271 @default.
- W2042196624 hasConcept C185592680 @default.
- W2042196624 hasConcept C2777622882 @default.
- W2042196624 hasConcept C2779422922 @default.
- W2042196624 hasConcept C2781443798 @default.
- W2042196624 hasConcept C3019368612 @default.
- W2042196624 hasConcept C519581460 @default.
- W2042196624 hasConcept C529295009 @default.
- W2042196624 hasConcept C71924100 @default.
- W2042196624 hasConcept C86803240 @default.
- W2042196624 hasConceptScore W2042196624C126322002 @default.
- W2042196624 hasConceptScore W2042196624C142724271 @default.
- W2042196624 hasConceptScore W2042196624C185592680 @default.
- W2042196624 hasConceptScore W2042196624C2777622882 @default.
- W2042196624 hasConceptScore W2042196624C2779422922 @default.
- W2042196624 hasConceptScore W2042196624C2781443798 @default.
- W2042196624 hasConceptScore W2042196624C3019368612 @default.
- W2042196624 hasConceptScore W2042196624C519581460 @default.
- W2042196624 hasConceptScore W2042196624C529295009 @default.
- W2042196624 hasConceptScore W2042196624C71924100 @default.
- W2042196624 hasConceptScore W2042196624C86803240 @default.
- W2042196624 hasIssue "10" @default.
- W2042196624 hasLocation W20421966241 @default.
- W2042196624 hasLocation W20421966242 @default.
- W2042196624 hasOpenAccess W2042196624 @default.
- W2042196624 hasPrimaryLocation W20421966241 @default.
- W2042196624 hasRelatedWork W2000811201 @default.
- W2042196624 hasRelatedWork W2020214793 @default.
- W2042196624 hasRelatedWork W2069374222 @default.
- W2042196624 hasRelatedWork W2087365675 @default.
- W2042196624 hasRelatedWork W2092710627 @default.
- W2042196624 hasRelatedWork W2165501377 @default.
- W2042196624 hasRelatedWork W2330169650 @default.
- W2042196624 hasRelatedWork W2379662269 @default.
- W2042196624 hasRelatedWork W2412524478 @default.
- W2042196624 hasRelatedWork W344627844 @default.
- W2042196624 hasVolume "15" @default.
- W2042196624 isParatext "false" @default.
- W2042196624 isRetracted "false" @default.
- W2042196624 magId "2042196624" @default.
- W2042196624 workType "article" @default.