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- W2042208046 endingPage "1719" @default.
- W2042208046 startingPage "1712" @default.
- W2042208046 abstract "Research on all stages of fibrin polymerization, using a variety of approaches including naturally occurring and recombinant variants of fibrinogen, x-ray crystallography, electron and light microscopy, and other biophysical approaches, has revealed aspects of the molecular mechanisms involved. The ordered sequence of fibrinopeptide release is essential for the knob-hole interactions that initiate oligomer formation and the subsequent formation of 2-stranded protofibrils. Calcium ions bound both strongly and weakly to fibrin(ogen) have been localized, and some aspects of their roles are beginning to be discovered. Much less is known about the mechanisms of the lateral aggregation of protofibrils and the subsequent branching to yield a 3-dimensional network, although the αC region and B:b knob-hole binding seem to enhance lateral aggregation. Much information now exists about variations in clot structure and properties because of genetic and acquired molecular variants, environmental factors, effects of various intravascular and extravascular cells, hydrodynamic flow, and some functional consequences. The mechanical and chemical stability of clots and thrombi are affected by both the structure of the fibrin network and cross-linking by plasma transglutaminase. There are important clinical consequences to all of these new findings that are relevant for the pathogenesis of diseases, prophylaxis, diagnosis, and treatment." @default.
- W2042208046 created "2016-06-24" @default.
- W2042208046 creator A5007009397 @default.
- W2042208046 creator A5089911552 @default.
- W2042208046 date "2013-03-07" @default.
- W2042208046 modified "2023-10-18" @default.
- W2042208046 title "Mechanisms of fibrin polymerization and clinical implications" @default.
- W2042208046 cites W1533637173 @default.
- W2042208046 cites W1543804368 @default.
- W2042208046 cites W1551874386 @default.
- W2042208046 cites W1590478914 @default.
- W2042208046 cites W1601899251 @default.
- W2042208046 cites W1711208506 @default.
- W2042208046 cites W1835746053 @default.
- W2042208046 cites W1955465780 @default.
- W2042208046 cites W1967652100 @default.
- W2042208046 cites W1972282939 @default.
- W2042208046 cites W1980346550 @default.
- W2042208046 cites W1985705459 @default.
- W2042208046 cites W1987102104 @default.
- W2042208046 cites W1987562115 @default.
- W2042208046 cites W1988873606 @default.
- W2042208046 cites W1989144240 @default.
- W2042208046 cites W1991257779 @default.
- W2042208046 cites W1993401250 @default.
- W2042208046 cites W1994007436 @default.
- W2042208046 cites W1995171177 @default.
- W2042208046 cites W1997614271 @default.
- W2042208046 cites W1998529033 @default.
- W2042208046 cites W1999981955 @default.
- W2042208046 cites W2000917871 @default.
- W2042208046 cites W2006656444 @default.
- W2042208046 cites W2006926412 @default.
- W2042208046 cites W2009581572 @default.
- W2042208046 cites W2009894847 @default.
- W2042208046 cites W2011190033 @default.
- W2042208046 cites W2017466351 @default.
- W2042208046 cites W2017976662 @default.
- W2042208046 cites W2020611424 @default.
- W2042208046 cites W2022816951 @default.
- W2042208046 cites W2023122926 @default.
- W2042208046 cites W2025624165 @default.
- W2042208046 cites W2027230418 @default.
- W2042208046 cites W2028695312 @default.
- W2042208046 cites W2029634939 @default.
- W2042208046 cites W2031311719 @default.
- W2042208046 cites W2035998381 @default.
- W2042208046 cites W2038164789 @default.
- W2042208046 cites W2039524544 @default.
- W2042208046 cites W2040081506 @default.
- W2042208046 cites W2042549988 @default.
- W2042208046 cites W2043471126 @default.
- W2042208046 cites W2043932794 @default.
- W2042208046 cites W2045555091 @default.
- W2042208046 cites W2046971159 @default.
- W2042208046 cites W2047181784 @default.
- W2042208046 cites W2047682340 @default.
- W2042208046 cites W2049954454 @default.
- W2042208046 cites W2052101764 @default.
- W2042208046 cites W2055369991 @default.
- W2042208046 cites W2056423944 @default.
- W2042208046 cites W2058842531 @default.
- W2042208046 cites W2062224910 @default.
- W2042208046 cites W2063869579 @default.
- W2042208046 cites W2066811457 @default.
- W2042208046 cites W2069354577 @default.
- W2042208046 cites W2069516813 @default.
- W2042208046 cites W2070484351 @default.
- W2042208046 cites W2071873580 @default.
- W2042208046 cites W2072072409 @default.
- W2042208046 cites W2072224196 @default.
- W2042208046 cites W2073159733 @default.
- W2042208046 cites W2079580065 @default.
- W2042208046 cites W2081136257 @default.
- W2042208046 cites W2083814433 @default.
- W2042208046 cites W2086099682 @default.
- W2042208046 cites W2088059845 @default.
- W2042208046 cites W2088605851 @default.
- W2042208046 cites W2089806980 @default.
- W2042208046 cites W2093577650 @default.
- W2042208046 cites W2095486848 @default.
- W2042208046 cites W2097690679 @default.
- W2042208046 cites W2102137160 @default.
- W2042208046 cites W2103509293 @default.
- W2042208046 cites W2107371049 @default.
- W2042208046 cites W2111904298 @default.
- W2042208046 cites W2116209993 @default.
- W2042208046 cites W2120474997 @default.
- W2042208046 cites W2120677427 @default.
- W2042208046 cites W2127141478 @default.
- W2042208046 cites W2132244872 @default.
- W2042208046 cites W2132612915 @default.
- W2042208046 cites W2140616436 @default.
- W2042208046 cites W2141827979 @default.
- W2042208046 cites W2145902566 @default.
- W2042208046 cites W2146619312 @default.
- W2042208046 cites W2154036638 @default.
- W2042208046 cites W2163470200 @default.