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- W2042210455 abstract "Because the complete pharmacology and toxicology of dilantinsodium, recently introduced for the treatment of epilepsy, are still unknown and because there is, as yet, a paucity of reports of acute poisoning from the drug, the following case is recorded. Dilantin sodium was introduced as an anticonvulsant by Merritt and Putnam<sup>1</sup>and has been reported on by many investigators. The structure of dilantin sodium (sodium diphenyl hydantoinate) is analogous to that of the barbiturates but it is a derivative of glycolyl urea instead of malonyl urea. The mode of action and the intermediate metabolism and excretion are not yet known. The mild toxic effects produced in some cases by poorly tolerated doses of dilantin sodium can be divided into two groups.<sup>2</sup>The first group is common to phenobarbital and to dilantin sodium and consists of lethargy, ataxia, anorexia, nystagmus and tremor; the second group is characteristic for toxic doses" @default.
- W2042210455 created "2016-06-24" @default.
- W2042210455 creator A5050430008 @default.
- W2042210455 date "1940-07-27" @default.
- W2042210455 modified "2023-09-26" @default.
- W2042210455 title "CASE OF ACUTE POISONING FROM DILANTIN SODIUM WITH RECOVERY" @default.
- W2042210455 cites W1973771108 @default.
- W2042210455 cites W2062230874 @default.
- W2042210455 cites W2103972588 @default.
- W2042210455 doi "https://doi.org/10.1001/jama.1940.72810300003007a" @default.
- W2042210455 hasPublicationYear "1940" @default.
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