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- W2042211237 abstract "1. Evidence derived both from spectrometric and incubation studies shows that microsomes prepared by contemporary methods of differential centrifugation exhibit appreciable mitochondrial-like activity. This is particularly demonstrable in incubation studies where the addition of the mitochondrial cytochrome P-450 reductase system (which is soluble and is extracted from the system by conventional produres) markedly increases IIβ-hydroxylation. The presence of significant quantities of mitochondrial-like cytochrome P-450 in microsomal preparations offers explanations for spectral responses to various steriod substrates observed in microsomal preparations. Induced difference spectra occur in these preparations both with II-deoxysteroid and 21-deoxysteroid substrates. 2. The magnitude of spectral response induced by androstenedione in microsomal preparations is markedly different in comparison to that induced by II-deoxycorticosterone. Androstenedione induces the greatest absorption minimum at 420 nm. After inducing the maximal spectral response possible with II-deoxycorticosterone, subsequent addition of androstenedione results in a deepening of the absorption minimum at 420 nm. This suggests that androstenedione, which serves as a substrate for IIβ-hydroxylation, responds with both mitochondrial and microsomal cytochrome P-450 moieties in these preparations. The former seems likely associated with the IIβ-hydroxylation reaction, the latter remains unexplained." @default.
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- W2042211237 date "1970-07-21" @default.
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- W2042211237 title "II-deoxysteroid-induced spectral responses in adrenal gland microsomes" @default.
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- W2042211237 doi "https://doi.org/10.1016/0304-4165(70)90394-6" @default.
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