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• W2042227511 abstract "In A 7 r 5 vascular smooth muscle cultures basal Ca 2+ influx was higher in growing versus quiescent cells (P < 0.05), due primarily to a five-fold increase in dihydropyridine-inhibitable Ca 2+ influx (P < 0.005). Verapamil decreased [ 3 H]thymidine incorporation in a concentration dependent fashion with a significant 6 ± 2% inhibition at 0.1 μM and a maximal inhibition of 67 ± 2% at 100 μM. Similarly, nitrendipine inhibited fetal calf serum-stimulated [ 3 H]thymidine incorporation with a threshold concentration of 1 nM and a maximal inhibition of 79 ± 12% at 10 μM. In quiescent cells, verapamil (10 μM) inhibited the increases in [ 3 H]thymidine incorporation stimulated by fetal calf serum, serotonin, vasopressin or 12-0-tetradecanoyl phorbol-13-acetate by 37–43% (P < 0.001 vs. control for all). Finally, verapamil (100 μM) and nitrendipine (10 μM) inhibited proliferation by 39 ± 10 and 20 ± 6%, respectively (P < 0.01 and 0.02 vs. control, respectively). Thus in A 7 r 5 cells, proliferation is associated with increased Ca 2+ influx via dihydropyridine-sensitive Ca 2+ channels and organic Ca 2+ channel antagonists inhibit DNA synthesis and cell proliferation." @default.
• W2042227511 created "2016-06-24" @default.
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• W2042227511 date "1991-04-01" @default.
• W2042227511 modified "2023-10-11" @default.
• W2042227511 title "Calcium influx modulates DNA synthesis and proliferation in A7r5 vascular smooth muscle cells" @default.
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• W2042227511 doi "https://doi.org/10.1016/0922-4106(91)90110-4" @default.
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