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- W2042240622 abstract "Abstract 1. 1. To have a maximum yield of mutants resistant to streptomycin after a treatment with HNO2 or ethyl methane sulfonate, it is necessary to keep the Escherichia coli cells in a nutritive medium for several hours before the application of the antibiotic. 2. 2. The delay must be longer when the action of the mutagen is heavier or when the culture medium is poorer. 3. 3. The delay is the sum of two parts: a latency without bacterial growth; a segregation of mutated DNA chains by nuclear multiplications and cell divisions. 4. 4. The intensity of the treatment by the mutagen affects mostly the latency period before bacterial growth, during which DNA repair occurs. 5. 5. Most of the mutants identified by the technique as resistant, are really dependent on streptomycin and show a rather poor growth even in the presence of the antibiotic. 6. 6. The treatment by ethyl methane sulfonate as well as by HNO2 must induce two to three simultaneous alterations within a sensitive region of a DNA chain to give a mutation to streptomycin resistance. 7. 7. Using a radioisotope, it has been shown that, in the case of the action of ethyl methane sulfonate, the sensitive region in a DNA chain is constituted by very few guanines. It is even likely that the guanines to be alkylated to obtain the mutation are strictly specified. 8. 8. These results would mean that two or three amino acids of the protein of the 30-S subunits of the ribosomes have to be changed to get streptomycin resistance (which is most often dependence). The substitution might be unique when the mutation is obtained with ethyl methane sulfonate." @default.
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- W2042240622 date "1967-10-01" @default.
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- W2042240622 title "A comparative study of the action of ethyl methane sulfonate and HNO2 on the mutation to streptomycin resistance of Escherichia coli K 12" @default.
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- W2042240622 doi "https://doi.org/10.1016/0005-2787(67)90134-7" @default.
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