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- W2042245441 abstract "CD4-positive T lymphocytes mainly direct immune as well as autoimmune responses against a variety of pathogens or allergens. This is achieved through the acquisition of specialized functions followed by differentiation into various T cell subsets. The differentiation process of naive T cells into effector subsets is regulated by dendritic cells and secreted cytokines. Signal transducer and activator of transcription proteins play critical roles in transmitting cytokine-mediated signals and specifying T cell differentiation. Epigenetic changes such as histone acetylation and methylation along with DNA methylation also regulate expression of differentiation-specific genes. Defining exactly how extrinsic signals control the specification of T cells will provide important insights and therapeutic opportunities." @default.
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- W2042245441 date "2012-10-09" @default.
- W2042245441 modified "2023-09-30" @default.
- W2042245441 title "Elucidating the regulation of T cell subsets" @default.
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- W2042245441 doi "https://doi.org/10.3892/ijmm.2012.1152" @default.
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