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- W2042247214 abstract "The authors investigated the dependence on extracellular and intracellular free Ca2+ in the induction of apoptosis and secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) by tumour necrosis factor (TNF) in a rat/mouse T cell hybridoma PC60 R55/R75, using the Ca2+ chelators EGTA and BAPTA/AM, respectively. TNF-induced apoptosis still occurred in the absence of free Ca2+, while GM-CSF production required the continuous presence of Ca2+. The latter was also true for GM-CSF production driven by interleukin 1 (IL-1). The dependence on Ca2+ in the induction of GM-CSF, but not of apoptosis, was further confirmed by the inhibition of TNF- or IL-1-induced cytokine production by cyclosporin A or FK506, drugs that block the Ca2+/calmodulin-dependent protein Ser/Thr phosphatase calcineurin. This differential requirement for Ca2+ illustrates the partial functional redundancy between TNF and IL-1, showing the activation of cytokine gene expression through a Ca(2+)-dependent activation of calcineurin, and a Ca(2+)-independent activation of apoptosis, exerted solely by TNF." @default.
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- W2042247214 date "1997-09-01" @default.
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- W2042247214 title "DIFFERENTIAL ROLE OF CALCIUM IN TUMOUR NECROSIS FACTOR-MEDIATED APOPTOSIS AND SECRETION OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN A T CELL HYBRIDOMA" @default.
- W2042247214 doi "https://doi.org/10.1006/cyto.1997.0218" @default.
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