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• W2042247941 abstract "<b>Background: </b> Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the oldest old (>85 years old) is largely unknown. <b>Methods: </b> A total of 132 formalin-fixed brains from the Vantaa 85+ community-based study were subjected to postmortem MRI. Visual ratings of MTA were determined in a blinded fashion and compared with neuropathologic findings and clinical assessment (dementia according to Diagnostic and Statistical Manual of Mental Disorders-III-R). <b>Results: </b> A strong relationship was found between MTA scores and Alzheimer pathology (<i>p</i> < 0.001). The previously proposed cutoff MTA score >2 correctly excluded subjects with no or borderline Alzheimer-type pathology (45/48), but was not very sensitive for AD (modified National Institute on Aging-Reagan Institute criteria). MTA scores >2 were also found in subjects with other primary neurodegenerative hippocampal pathology including hippocampal sclerosis, Lewy-related pathology, and argyrophilic grain disease, either alone or in combination with Alzheimer-type pathology. High MTA scores were associated with clinical dementia—in this subgroup, sensitivity was 63% and specificity 69% for AD. <b>Conclusion: </b> Medial temporal lobe atrophy (MTA) on postmortem MRI is sensitive to primary degenerative hippocampal pathology in the very old, but not specific for Alzheimer-type pathology. MTA scores of 2 or less are not frequently associated with dementia. <b>GLOSSARY: </b><b>AD</b> = Alzheimer disease; <b>AgD</b> = argyrophilic grain disease; <b>CERAD</b> = Consortium to Establish a Registry for Alzheimer’s Disease; <b>DLB</b> = dementia with Lewy bodies; <b>HS</b> = hippocampal sclerosis; <b>L-rP</b> = Lewy-related pathology; <b>MCI</b> = mild cognitive impairment; <b>MTA</b> = medial temporal lobe atrophy." @default.
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• W2042247941 date "2007-10-08" @default.
• W2042247941 modified "2023-10-18" @default.
• W2042247941 title "The significance of medial temporal lobe atrophy: A postmortem MRI study in the very old" @default.
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• W2042247941 doi "https://doi.org/10.1212/01.wnl.0000277459.83543.99" @default.
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