Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042250021> ?p ?o ?g. }
- W2042250021 endingPage "483" @default.
- W2042250021 startingPage "469" @default.
- W2042250021 abstract "Regeneration of optic axons in the continuously growing optic system of adult zebrafish was analyzed by anterograde tracing and correlated with the mRNA expression patterns of the recognition molecules ephrin-A2 and ephrin-A5b in retinal targets. The optic tectum and diencephalic targets are all reinnervated after a lesion. However, the rate of erroneous pathway choices was increased at the chiasm and the bifurcation between the ventral and dorsal brachium of the optic tract compared to unlesioned animals. Tracer application to different retinal positions revealed retinotopic reinnervation of the tectum within 4 weeks after the lesion. In situ hybridization analysis indicated the presence of rostral-low to caudal-high gradients of ephrin-A2 and ephrin-A5b mRNAs in unlesioned control tecta and after a unilateral optic nerve lesion. By contrast, the parvocellular superficial pretectal nucleus showed retinotopic organization of optic fibers but no detectable expression of ephrin-A2 and ephrin-A5b mRNAs. However, a row of cells delineating the terminal field of optic fibers in the dorsal part of the periventricular pretectal nucleus was intensely labeled for ephrin-A5b mRNA and may thus provide a stop signal for ingrowing axons. Ephrin-A2 and ephrin-A5b mRNAs were not detectable in the adult retina, despite their prominent expression during development. Thus, given a complementary receptor system in retinal ganglion cells, expression of ephrin-A2 and ephrin-A5b in primary targets of optic fibers in adult zebrafish may contribute to guidance of optic axons that are continuously added to the adult projection and of regenerating axons after optic nerve lesion. J. Comp. Neurol. 427:469–483, 2000. © 2000 Wiley-Liss, Inc." @default.
- W2042250021 created "2016-06-24" @default.
- W2042250021 creator A5081370735 @default.
- W2042250021 creator A5081747194 @default.
- W2042250021 date "2000-01-01" @default.
- W2042250021 modified "2023-10-16" @default.
- W2042250021 title "Gradients of ephrin-A2 and ephrin-A5b mRNA during retinotopic regeneration of the optic projection in adult zebrafish" @default.
- W2042250021 cites W119375474 @default.
- W2042250021 cites W1547986833 @default.
- W2042250021 cites W1584418883 @default.
- W2042250021 cites W1626699932 @default.
- W2042250021 cites W1827800528 @default.
- W2042250021 cites W1839115007 @default.
- W2042250021 cites W1912704046 @default.
- W2042250021 cites W1958799509 @default.
- W2042250021 cites W1965240654 @default.
- W2042250021 cites W1967078733 @default.
- W2042250021 cites W1967876354 @default.
- W2042250021 cites W1977455576 @default.
- W2042250021 cites W1981268970 @default.
- W2042250021 cites W1982024326 @default.
- W2042250021 cites W1984755886 @default.
- W2042250021 cites W1986340616 @default.
- W2042250021 cites W1988490574 @default.
- W2042250021 cites W1990956997 @default.
- W2042250021 cites W1994713664 @default.
- W2042250021 cites W1994784385 @default.
- W2042250021 cites W1998312044 @default.
- W2042250021 cites W1998944071 @default.
- W2042250021 cites W2001392545 @default.
- W2042250021 cites W2003445625 @default.
- W2042250021 cites W2011611925 @default.
- W2042250021 cites W2012062217 @default.
- W2042250021 cites W2021025315 @default.
- W2042250021 cites W2024067326 @default.
- W2042250021 cites W2033220760 @default.
- W2042250021 cites W2036024192 @default.
- W2042250021 cites W2037955633 @default.
- W2042250021 cites W2041710261 @default.
- W2042250021 cites W2043562994 @default.
- W2042250021 cites W2044751105 @default.
- W2042250021 cites W2046473731 @default.
- W2042250021 cites W2049141731 @default.
- W2042250021 cites W2049325499 @default.
- W2042250021 cites W2055307195 @default.
- W2042250021 cites W2056068926 @default.
- W2042250021 cites W2057932143 @default.
- W2042250021 cites W2061697147 @default.
- W2042250021 cites W2064464683 @default.
- W2042250021 cites W2065509542 @default.
- W2042250021 cites W2066798120 @default.
- W2042250021 cites W2071313161 @default.
- W2042250021 cites W2074480164 @default.
- W2042250021 cites W2074705177 @default.
- W2042250021 cites W2076585835 @default.
- W2042250021 cites W2080576703 @default.
- W2042250021 cites W2082155614 @default.
- W2042250021 cites W2085462828 @default.
- W2042250021 cites W2086288271 @default.
- W2042250021 cites W2089705588 @default.
- W2042250021 cites W2090505541 @default.
- W2042250021 cites W2094722924 @default.
- W2042250021 cites W2108613636 @default.
- W2042250021 cites W2110998704 @default.
- W2042250021 cites W2120760119 @default.
- W2042250021 cites W2122587655 @default.
- W2042250021 cites W2129076056 @default.
- W2042250021 cites W2131178888 @default.
- W2042250021 cites W2133991409 @default.
- W2042250021 cites W2139225329 @default.
- W2042250021 cites W2148600260 @default.
- W2042250021 cites W2155666894 @default.
- W2042250021 cites W2163297587 @default.
- W2042250021 cites W2167581922 @default.
- W2042250021 cites W2171725531 @default.
- W2042250021 cites W2184257663 @default.
- W2042250021 cites W2185351394 @default.
- W2042250021 cites W2311846232 @default.
- W2042250021 cites W2331176706 @default.
- W2042250021 cites W2484659268 @default.
- W2042250021 cites W351914998 @default.
- W2042250021 cites W4242530862 @default.
- W2042250021 cites W4299521546 @default.
- W2042250021 cites W81627589 @default.
- W2042250021 doi "https://doi.org/10.1002/1096-9861(20001120)427:3<469::aid-cne12>3.0.co;2-n" @default.
- W2042250021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054707" @default.
- W2042250021 hasPublicationYear "2000" @default.
- W2042250021 type Work @default.
- W2042250021 sameAs 2042250021 @default.
- W2042250021 citedByCount "59" @default.
- W2042250021 countsByYear W20422500212013 @default.
- W2042250021 countsByYear W20422500212014 @default.
- W2042250021 countsByYear W20422500212015 @default.
- W2042250021 countsByYear W20422500212017 @default.
- W2042250021 countsByYear W20422500212018 @default.
- W2042250021 countsByYear W20422500212019 @default.
- W2042250021 countsByYear W20422500212020 @default.
- W2042250021 countsByYear W20422500212022 @default.