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• W2042252389 abstract "Thromboxane (Tx)B 2 and 6-keto-prostaglandin (6-keto-PG) F 1α formation in the hippocampus and caudate nucleus were evaluated by microdialysis during and following forebrain ischemia. Spontaneously hypertensive rats were subjected to bilateral carotid artery occlusion with simultaneous hypotension for 8, 14, or 20 min. Dialysate was collected during the ischemic interval and during the reperfusion period. TxB 2 and 6-keto-PGF 1α levels were measured by radioimmunoassay. In both structures, TxB 2 production increased significantly during the reperfusion period in all three ischemic groups. By contrast, increased 6-keto-PGF 1α elaboration was observed after only the longest ischemic duration. While TxB 2 levels gradually decreased during the 3-h reperfusion period in all groups, the levels in the group subjected to 8 min of ischemia returned to control values most rapidly. A relationship between the duration of ischemia and TxB 2 production was therefore evident. 6-Keto-PGF 1α levels increased in only the group subjected to 20 min of ischemia and, by contrast to the pattern of TxB 2 change, 6-keto-PGF 1α levels remained elevated throughout the reperfusion period. During reperfusion, the ratio of TxB 2 to 6-keto-PGF 1α increased substantially versus the preischemic period in both structures. The data demonstrate that eicosanoid elaboration following cerebral ischemia can be evaluated by the microdialysis technique. In addition, they indicate that the thresholds (duration of ischemia) for the postischemic production and the temporal profiles of TxB 2 and 6-keto-PGF 1α in the caudate and hippocampus differ. They also demonstrate that there is regional heterogeneity in the patterns of eicosanoid elaboration after forebrain ischemia." @default.
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• W2042252389 date "1992-01-01" @default.
• W2042252389 modified "2023-10-12" @default.
• W2042252389 title "Eicosanoid Production in the Caudate Nucleus and Dorsal Hippocampus after Forebrain Ischemia: A Microdialysis Study" @default.
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• W2042252389 doi "https://doi.org/10.1038/jcbfm.1992.11" @default.
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