FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042253755> ?p ?o ?g. }

• W2042253755 endingPage "1540" @default.
• W2042253755 startingPage "1531" @default.
• W2042253755 abstract "MDA-MB-231 cells are highly aggressive human breast adenocarcinoma cells that depend on PLD activity for survival. In response to the stress of serum withdrawal, there is increased motility and invasiveness of these cells that is associated with a rapid increase in PLD activity. In addition, PLD activity is elevated in response to most mitogenic signals. Similar to PLD, paxillin, a focal adhesion adaptor protein, and Erk, mitogen-activated protein kinase, play vital roles in cell motility through regulation of focal adhesion dynamics. Here, we addressed whether there is a functional correlation between paxillin and PLD that may influence cancer cell motility. We investigated the role of PLD activity on paxillin regulation, Erk activation and formation of a paxillin–Erk and paxillin–FAK association. Inhibition of PLD activity led to an increase in paxillin tyrosine phosphorylation, a decrease in Erk activation, as measured by phosphorylation, and enhanced association of paxillin with Erk. In addition, we found that paxillin tyrosine phosphorylation depends upon Erk activity and may be a consequence of an increased association with FAK. Taken together, these results suggest that Erk activity is governed by PLD activity and regulates the tyrosine phosphorylation of paxillin, potentially explaining its role in cell motility. This study indicated that PLD, Erk, paxillin and FAK participate in the same signaling pathway in this breast cancer cell line." @default.
• W2042253755 created "2016-06-24" @default.
• W2042253755 creator A5030304398 @default.
• W2042253755 creator A5076739498 @default.
• W2042253755 date "2012-08-01" @default.
• W2042253755 modified "2023-10-16" @default.
• W2042253755 title "Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells" @default.
• W2042253755 cites W1488252042 @default.
• W2042253755 cites W1537898230 @default.
• W2042253755 cites W1969689864 @default.
• W2042253755 cites W1972612436 @default.
• W2042253755 cites W1973834617 @default.
• W2042253755 cites W1976331372 @default.
• W2042253755 cites W1981813507 @default.
• W2042253755 cites W1981972757 @default.
• W2042253755 cites W1982501876 @default.
• W2042253755 cites W1983651221 @default.
• W2042253755 cites W1985961293 @default.
• W2042253755 cites W1991738330 @default.
• W2042253755 cites W1997692142 @default.
• W2042253755 cites W2007375100 @default.
• W2042253755 cites W2007897263 @default.
• W2042253755 cites W2012228628 @default.
• W2042253755 cites W2021064989 @default.
• W2042253755 cites W2023586869 @default.
• W2042253755 cites W2025721244 @default.
• W2042253755 cites W2031429840 @default.
• W2042253755 cites W2034070845 @default.
• W2042253755 cites W2036446081 @default.
• W2042253755 cites W2038963002 @default.
• W2042253755 cites W2041822723 @default.
• W2042253755 cites W2043226961 @default.
• W2042253755 cites W2053768649 @default.
• W2042253755 cites W2053844592 @default.
• W2042253755 cites W2058843151 @default.
• W2042253755 cites W2059086985 @default.
• W2042253755 cites W2059986736 @default.
• W2042253755 cites W2060630008 @default.
• W2042253755 cites W2073513388 @default.
• W2042253755 cites W2075612906 @default.
• W2042253755 cites W2081869055 @default.
• W2042253755 cites W2087663072 @default.
• W2042253755 cites W2093999584 @default.
• W2042253755 cites W2097672376 @default.
• W2042253755 cites W2101634748 @default.
• W2042253755 cites W2102888099 @default.
• W2042253755 cites W2109276980 @default.
• W2042253755 cites W2109504086 @default.
• W2042253755 cites W2118689626 @default.
• W2042253755 cites W2128333867 @default.
• W2042253755 cites W2130198938 @default.
• W2042253755 cites W2138231208 @default.
• W2042253755 cites W2139560640 @default.
• W2042253755 cites W2140506935 @default.
• W2042253755 cites W214799791 @default.
• W2042253755 cites W2152289580 @default.
• W2042253755 cites W2154524184 @default.
• W2042253755 cites W2157529751 @default.
• W2042253755 cites W2167409254 @default.
• W2042253755 cites W2184788214 @default.
• W2042253755 cites W2280177159 @default.
• W2042253755 cites W2315825931 @default.
• W2042253755 cites W2413964541 @default.
• W2042253755 cites W4213174658 @default.
• W2042253755 cites W4250702405 @default.
• W2042253755 cites W72550747 @default.
• W2042253755 doi "https://doi.org/10.1016/j.cellsig.2012.03.015" @default.
• W2042253755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3397919" @default.
• W2042253755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22481092" @default.
• W2042253755 hasPublicationYear "2012" @default.
• W2042253755 type Work @default.
• W2042253755 sameAs 2042253755 @default.
• W2042253755 citedByCount "7" @default.
• W2042253755 countsByYear W20422537552013 @default.
• W2042253755 countsByYear W20422537552014 @default.
• W2042253755 countsByYear W20422537552015 @default.
• W2042253755 countsByYear W20422537552017 @default.
• W2042253755 countsByYear W20422537552023 @default.
• W2042253755 crossrefType "journal-article" @default.
• W2042253755 hasAuthorship W2042253755A5030304398 @default.
• W2042253755 hasAuthorship W2042253755A5076739498 @default.
• W2042253755 hasBestOaLocation W20422537552 @default.
• W2042253755 hasConcept C108391706 @default.
• W2042253755 hasConcept C116581196 @default.
• W2042253755 hasConcept C11960822 @default.
• W2042253755 hasConcept C151166631 @default.
• W2042253755 hasConcept C185592680 @default.
• W2042253755 hasConcept C2777553839 @default.
• W2042253755 hasConcept C502942594 @default.
• W2042253755 hasConcept C57074206 @default.
• W2042253755 hasConcept C58207958 @default.
• W2042253755 hasConcept C86803240 @default.
• W2042253755 hasConcept C90934575 @default.
• W2042253755 hasConcept C95444343 @default.
• W2042253755 hasConcept C97029542 @default.
• W2042253755 hasConceptScore W2042253755C108391706 @default.
• W2042253755 hasConceptScore W2042253755C116581196 @default.
• W2042253755 hasConceptScore W2042253755C11960822 @default.

• next