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• W2042253757 abstract "We demonstrate that precursors of U1 snRNA are associated with nuclear proteins prior to export to the cytoplasm. The approximately 15S complexes containing pre-U1 RNA, which we call pre-export U1 snRNPs, were identified in extracts of Xenopus laevis oocyte nuclei that were synthesizing U1 RNAs from injected U1 genes. The U1 snRNP-specific A protein was associated with nuclear pre-U1 RNA since both this protein and the RNA were co-precipitated by antibodies directed against either the m7G-cap of the precursor RNA or the U1-A protein. The interaction of the U1-A protein with pre-U1 RNA required sequences in the loop II region although this region of U1 RNA was not necessary for the association of U1 A protein with mature U1 snRNPs. The U1 A protein helps protect pre-U1 RNA against degradation in the nucleus." @default.
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• W2042253757 date "1993-01-01" @default.
• W2042253757 modified "2023-10-16" @default.
• W2042253757 title "A pre-export U1 snRNP in<i>Xenopus laevis</i>oocyte nuclei" @default.
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• W2042253757 doi "https://doi.org/10.1093/nar/21.19.4569" @default.
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