Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042255185> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2042255185 abstract "1. A number of metabolites of oxapadol were isolated from urine of rat, dog and man after administration of a single dose of 14C-labelled compound. They were identified by direct inlet mass spectrometry and chromatographic comparison with reference compounds. 2. Oxapadol was extensively metabolized and the unchanged drug was undetectable in rat or human urine; only traces were found in dog urine. Nine metabolites were identified in rat and dog urine, and six in man. 3. The routes of biotransformation were: (a) aromatic hydroxylation, mainly in the benzimidazole ring, (b) scission of the heterocyclic ring following two different pathways, and (c) a combination of the two. Regioselectivity was observed for aromatic hydroxylation, as only three of the four possible monohydroxy oxazepinobenzimidazoles could be detected." @default.
- W2042255185 created "2016-06-24" @default.
- W2042255185 creator A5003172446 @default.
- W2042255185 creator A5006788395 @default.
- W2042255185 creator A5019016165 @default.
- W2042255185 creator A5035392096 @default.
- W2042255185 creator A5062409216 @default.
- W2042255185 date "1981-01-01" @default.
- W2042255185 modified "2023-09-25" @default.
- W2042255185 title "Urinary metabolites of oxapadol (MD720111), a new non-narcotic analgesic agent, in the rat, dog and man" @default.
- W2042255185 cites W1510749501 @default.
- W2042255185 cites W1589004855 @default.
- W2042255185 cites W1980467365 @default.
- W2042255185 cites W1986407552 @default.
- W2042255185 cites W1988158410 @default.
- W2042255185 cites W1989723714 @default.
- W2042255185 cites W2082020812 @default.
- W2042255185 cites W2086371393 @default.
- W2042255185 cites W2104973290 @default.
- W2042255185 doi "https://doi.org/10.3109/00498258109045863" @default.
- W2042255185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7303722" @default.
- W2042255185 hasPublicationYear "1981" @default.
- W2042255185 type Work @default.
- W2042255185 sameAs 2042255185 @default.
- W2042255185 citedByCount "2" @default.
- W2042255185 countsByYear W20422551852021 @default.
- W2042255185 crossrefType "journal-article" @default.
- W2042255185 hasAuthorship W2042255185A5003172446 @default.
- W2042255185 hasAuthorship W2042255185A5006788395 @default.
- W2042255185 hasAuthorship W2042255185A5019016165 @default.
- W2042255185 hasAuthorship W2042255185A5035392096 @default.
- W2042255185 hasAuthorship W2042255185A5062409216 @default.
- W2042255185 hasConcept C178790620 @default.
- W2042255185 hasConcept C181199279 @default.
- W2042255185 hasConcept C185592680 @default.
- W2042255185 hasConcept C2777477808 @default.
- W2042255185 hasConcept C2778484023 @default.
- W2042255185 hasConcept C2780026642 @default.
- W2042255185 hasConcept C2780820201 @default.
- W2042255185 hasConcept C2781109383 @default.
- W2042255185 hasConcept C27881333 @default.
- W2042255185 hasConcept C43617362 @default.
- W2042255185 hasConcept C55493867 @default.
- W2042255185 hasConcept C71924100 @default.
- W2042255185 hasConcept C98274493 @default.
- W2042255185 hasConceptScore W2042255185C178790620 @default.
- W2042255185 hasConceptScore W2042255185C181199279 @default.
- W2042255185 hasConceptScore W2042255185C185592680 @default.
- W2042255185 hasConceptScore W2042255185C2777477808 @default.
- W2042255185 hasConceptScore W2042255185C2778484023 @default.
- W2042255185 hasConceptScore W2042255185C2780026642 @default.
- W2042255185 hasConceptScore W2042255185C2780820201 @default.
- W2042255185 hasConceptScore W2042255185C2781109383 @default.
- W2042255185 hasConceptScore W2042255185C27881333 @default.
- W2042255185 hasConceptScore W2042255185C43617362 @default.
- W2042255185 hasConceptScore W2042255185C55493867 @default.
- W2042255185 hasConceptScore W2042255185C71924100 @default.
- W2042255185 hasConceptScore W2042255185C98274493 @default.
- W2042255185 hasLocation W20422551851 @default.
- W2042255185 hasLocation W20422551852 @default.
- W2042255185 hasOpenAccess W2042255185 @default.
- W2042255185 hasPrimaryLocation W20422551851 @default.
- W2042255185 hasRelatedWork W1969955256 @default.
- W2042255185 hasRelatedWork W2020630400 @default.
- W2042255185 hasRelatedWork W2030577223 @default.
- W2042255185 hasRelatedWork W2042255185 @default.
- W2042255185 hasRelatedWork W2067685349 @default.
- W2042255185 hasRelatedWork W2077509115 @default.
- W2042255185 hasRelatedWork W2185716984 @default.
- W2042255185 hasRelatedWork W2399751232 @default.
- W2042255185 hasRelatedWork W3194399020 @default.
- W2042255185 hasRelatedWork W21435082 @default.
- W2042255185 isParatext "false" @default.
- W2042255185 isRetracted "false" @default.
- W2042255185 magId "2042255185" @default.
- W2042255185 workType "article" @default.