FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042259377> ?p ?o ?g. }

• W2042259377 endingPage "4980" @default.
• W2042259377 startingPage "4980" @default.
• W2042259377 abstract "purpose. Herpes simplex virus (HSV)-1 infections of the human cornea range in severity from uncomplicated episodes that readily resolve to severe, recurring disease that invades the stroma, having a devastating permanent effect on vision. Recent published data implicate an apoptotic component to stromal HSV-1 infection. In a prior study, it was found that wild type (wt) HSV-1 infection induces, then blocks, apoptosis in epithelial cells derived from skin and that this block requires infected cell proteins (ICPs) synthesized between 3 and 6 hours post infection (hpi). This inhibition of apoptosis is in part dependent on the activation of inducible nuclear transcription factor κB (NF-κB). methods. HSV-1-dependent apoptosis in rabbit corneal epithelial (SIRC) cells was compared with that in infected human epithelial (HEp-2) cells. results. SIRC cells were sensitive to apoptotic cell death induced by environmental treatment with tumor necrosis factor (TNF)-α plus cycloheximide (CHX). HSV-1 stimulated the degradation of regulatory IκBα protein, resulting in nuclear translocation of NF-κB. This phenomenon was dependent on ICP synthesis. Neither wt nor apoptotic HSV-1 infection resulted in apoptosis in these cells. However, wt HSV-1-infected cells produced detectable levels of cleaved poly(ADP-ribose) (PARP). Inhibition of SIRC cell protein synthesis with CHX during wt HSV-1 infection led to a reduction in the amount of PARP cleavage. Whereas PARP cleavage defined cell death in most other cell types, its processing in SIRC cells was a reproducible characteristic of wt HSV-1 infection. conclusions. This is the first report of such an effect, and it suggests that in corneal epithelial cells, activation of apoptotic pathways may be necessary for productive viral replication. Thus, efficient replication of HSV-1 in the corneal milieu proceeds via a different mechanism than it does in skin. However, it appears that NF-κB participates in inhibiting apoptosis during HSV-1 infection in both systems." @default.
• W2042259377 created "2016-06-24" @default.
• W2042259377 creator A5001183684 @default.
• W2042259377 creator A5026160198 @default.
• W2042259377 creator A5031685210 @default.
• W2042259377 creator A5049410217 @default.
• W2042259377 date "2007-11-01" @default.
• W2042259377 modified "2023-10-07" @default.
• W2042259377 title "Nuclear Translocation of NF-κB Precedes Apoptotic Poly(ADP-ribose) Polymerase Cleavage during Productive HSV-1 Replication in Corneal Epithelial Cells" @default.
• W2042259377 cites W1548611677 @default.
• W2042259377 cites W1551656240 @default.
• W2042259377 cites W1579443490 @default.
• W2042259377 cites W1888783223 @default.
• W2042259377 cites W1926535247 @default.
• W2042259377 cites W1946913530 @default.
• W2042259377 cites W1976382352 @default.
• W2042259377 cites W1984209816 @default.
• W2042259377 cites W1991438508 @default.
• W2042259377 cites W1996696918 @default.
• W2042259377 cites W1998862354 @default.
• W2042259377 cites W2004897289 @default.
• W2042259377 cites W2010491850 @default.
• W2042259377 cites W2011007912 @default.
• W2042259377 cites W2032531389 @default.
• W2042259377 cites W2043039839 @default.
• W2042259377 cites W2062520454 @default.
• W2042259377 cites W2083190805 @default.
• W2042259377 cites W2098308748 @default.
• W2042259377 cites W2102297492 @default.
• W2042259377 cites W2105896882 @default.
• W2042259377 cites W2117597637 @default.
• W2042259377 cites W2121548978 @default.
• W2042259377 cites W2128016549 @default.
• W2042259377 cites W2129242841 @default.
• W2042259377 cites W2133784511 @default.
• W2042259377 cites W2147593691 @default.
• W2042259377 cites W2152941168 @default.
• W2042259377 cites W2154062558 @default.
• W2042259377 cites W2164152668 @default.
• W2042259377 cites W2171876106 @default.
• W2042259377 cites W2181565914 @default.
• W2042259377 cites W2332582619 @default.
• W2042259377 doi "https://doi.org/10.1167/iovs.07-0489" @default.
• W2042259377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17962448" @default.
• W2042259377 hasPublicationYear "2007" @default.
• W2042259377 type Work @default.
• W2042259377 sameAs 2042259377 @default.
• W2042259377 citedByCount "12" @default.
• W2042259377 countsByYear W20422593772012 @default.
• W2042259377 countsByYear W20422593772013 @default.
• W2042259377 countsByYear W20422593772014 @default.
• W2042259377 countsByYear W20422593772015 @default.
• W2042259377 countsByYear W20422593772018 @default.
• W2042259377 countsByYear W20422593772019 @default.
• W2042259377 countsByYear W20422593772023 @default.
• W2042259377 crossrefType "journal-article" @default.
• W2042259377 hasAuthorship W2042259377A5001183684 @default.
• W2042259377 hasAuthorship W2042259377A5026160198 @default.
• W2042259377 hasAuthorship W2042259377A5031685210 @default.
• W2042259377 hasAuthorship W2042259377A5049410217 @default.
• W2042259377 hasBestOaLocation W20422593771 @default.
• W2042259377 hasConcept C1491633281 @default.
• W2042259377 hasConcept C153911025 @default.
• W2042259377 hasConcept C159047783 @default.
• W2042259377 hasConcept C182979987 @default.
• W2042259377 hasConcept C190283241 @default.
• W2042259377 hasConcept C2778128677 @default.
• W2042259377 hasConcept C2779257441 @default.
• W2042259377 hasConcept C31573885 @default.
• W2042259377 hasConcept C3675279 @default.
• W2042259377 hasConcept C529295009 @default.
• W2042259377 hasConcept C54355233 @default.
• W2042259377 hasConcept C552990157 @default.
• W2042259377 hasConcept C55493867 @default.
• W2042259377 hasConcept C81885089 @default.
• W2042259377 hasConcept C82381507 @default.
• W2042259377 hasConcept C86803240 @default.
• W2042259377 hasConceptScore W2042259377C1491633281 @default.
• W2042259377 hasConceptScore W2042259377C153911025 @default.
• W2042259377 hasConceptScore W2042259377C159047783 @default.
• W2042259377 hasConceptScore W2042259377C182979987 @default.
• W2042259377 hasConceptScore W2042259377C190283241 @default.
• W2042259377 hasConceptScore W2042259377C2778128677 @default.
• W2042259377 hasConceptScore W2042259377C2779257441 @default.
• W2042259377 hasConceptScore W2042259377C31573885 @default.
• W2042259377 hasConceptScore W2042259377C3675279 @default.
• W2042259377 hasConceptScore W2042259377C529295009 @default.
• W2042259377 hasConceptScore W2042259377C54355233 @default.
• W2042259377 hasConceptScore W2042259377C552990157 @default.
• W2042259377 hasConceptScore W2042259377C55493867 @default.
• W2042259377 hasConceptScore W2042259377C81885089 @default.
• W2042259377 hasConceptScore W2042259377C82381507 @default.
• W2042259377 hasConceptScore W2042259377C86803240 @default.
• W2042259377 hasIssue "11" @default.
• W2042259377 hasLocation W20422593771 @default.
• W2042259377 hasLocation W20422593772 @default.
• W2042259377 hasOpenAccess W2042259377 @default.
• W2042259377 hasPrimaryLocation W20422593771 @default.

• next