FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042263265> ?p ?o ?g. }

• W2042263265 endingPage "107" @default.
• W2042263265 startingPage "77" @default.
• W2042263265 abstract "This paper explores the basis of schizophrenia from a neuroanatomical systems perspective. This perspective includes an analysis of the literature on the neurochemical, neurotransmitter, morphological, neurophysiological, connectional, developmental, neurosurgical, behavioral, neurological, and psychophysical aspects of schizophrenia. The convergence of evidence from these diverse subfields of inquiry are then mapped as interacting circuits throughout the neuraxis. Viewed from these specific and whole brain points of view, several patterns emerge. First, virtually all major brain areas and circuits in the brain have been implicated in the etiology and symptomotology of schizophrenia. This is consistent with the multiple forms of schizophrenia and the constellation of clinical syndromes associated with the different schizophrenias. Second, although numerous, widely dispersed circuits are implicated, all circuits directly impact connections and functions of the dorsal prefrontal cortex, and specifically the cortico-cortical and corticosubcortical pyramidal neuron outputs and loop systems back to these pyramidal neurons. The neuronal systems most intimately associated with regulation of pyramidal neuron function are local GABA-ergic interneuronal inputs, dopaminergic inputs, glutaminergic drive, and differential regulation of excitability and firing of these neurons by the segregated inputs and local receptor and channel properties of the distal vs proximal compartments of the pyramidal neurons. The dorsal and dorsolateral prefrontal cortex appears to be at particular risk to dysregulated inputs, whereas the orbital cortex appears to more protected from hypofunctionality, perhaps due, in part, from a richer array of cortico-cortical inputs, and a relative independence from cerebellar dysmetric influences. Other cortical areas of the temporal lobe are, to a lesser degree, influential in the primary neuronal dysfunctioning in schizophrenia. Thus, although many brain circuits and neurotransmitter systems are implicated in schizophrenia, their ultimate impact on the dorsal prefrontal cortex pyramidal neuron, appear to be the common cause in this disease." @default.
• W2042263265 created "2016-06-24" @default.
• W2042263265 creator A5029440199 @default.
• W2042263265 creator A5050834331 @default.
• W2042263265 creator A5088025134 @default.
• W2042263265 date "2003-05-01" @default.
• W2042263265 modified "2023-10-17" @default.
• W2042263265 title "The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems" @default.
• W2042263265 cites W1211088797 @default.
• W2042263265 cites W126907670 @default.
• W2042263265 cites W144271823 @default.
• W2042263265 cites W1485719988 @default.
• W2042263265 cites W1514573559 @default.
• W2042263265 cites W1521841439 @default.
• W2042263265 cites W1557303332 @default.
• W2042263265 cites W1568392634 @default.
• W2042263265 cites W166746879 @default.
• W2042263265 cites W1715498265 @default.
• W2042263265 cites W1796200935 @default.
• W2042263265 cites W1828538530 @default.
• W2042263265 cites W1854404651 @default.
• W2042263265 cites W1914270110 @default.
• W2042263265 cites W1926506078 @default.
• W2042263265 cites W1965767818 @default.
• W2042263265 cites W1966092598 @default.
• W2042263265 cites W1966515892 @default.
• W2042263265 cites W1967466600 @default.
• W2042263265 cites W1967880030 @default.
• W2042263265 cites W1968028752 @default.
• W2042263265 cites W1968629708 @default.
• W2042263265 cites W1968700646 @default.
• W2042263265 cites W1969123175 @default.
• W2042263265 cites W1969303073 @default.
• W2042263265 cites W1969397636 @default.
• W2042263265 cites W1969590947 @default.
• W2042263265 cites W1969694352 @default.
• W2042263265 cites W1970541082 @default.
• W2042263265 cites W1971646855 @default.
• W2042263265 cites W1972588943 @default.
• W2042263265 cites W1972620910 @default.
• W2042263265 cites W1972748738 @default.
• W2042263265 cites W1972777532 @default.
• W2042263265 cites W1973042782 @default.
• W2042263265 cites W1973073975 @default.
• W2042263265 cites W1973408650 @default.
• W2042263265 cites W1974058328 @default.
• W2042263265 cites W1975201511 @default.
• W2042263265 cites W1975310269 @default.
• W2042263265 cites W1975517485 @default.
• W2042263265 cites W1975740143 @default.
• W2042263265 cites W1975819296 @default.
• W2042263265 cites W1975996377 @default.
• W2042263265 cites W1977410909 @default.
• W2042263265 cites W1977711855 @default.
• W2042263265 cites W1978916822 @default.
• W2042263265 cites W1979413325 @default.
• W2042263265 cites W1979429075 @default.
• W2042263265 cites W1979480286 @default.
• W2042263265 cites W1979565242 @default.
• W2042263265 cites W1980776446 @default.
• W2042263265 cites W1981037740 @default.
• W2042263265 cites W1981665989 @default.
• W2042263265 cites W1981719311 @default.
• W2042263265 cites W1981727048 @default.
• W2042263265 cites W1982727835 @default.
• W2042263265 cites W1983651376 @default.
• W2042263265 cites W1984470001 @default.
• W2042263265 cites W1985146875 @default.
• W2042263265 cites W1985267538 @default.
• W2042263265 cites W1985994929 @default.
• W2042263265 cites W1986668301 @default.
• W2042263265 cites W1987498894 @default.
• W2042263265 cites W1988060537 @default.
• W2042263265 cites W1988584692 @default.
• W2042263265 cites W1988867234 @default.
• W2042263265 cites W1989029973 @default.
• W2042263265 cites W1990063240 @default.
• W2042263265 cites W1991706037 @default.
• W2042263265 cites W1992214067 @default.
• W2042263265 cites W1993206740 @default.
• W2042263265 cites W1994008515 @default.
• W2042263265 cites W1994483494 @default.
• W2042263265 cites W1994517931 @default.
• W2042263265 cites W1995362640 @default.
• W2042263265 cites W1995799202 @default.
• W2042263265 cites W1998704822 @default.
• W2042263265 cites W1999014668 @default.
• W2042263265 cites W1999668406 @default.
• W2042263265 cites W2001486260 @default.
• W2042263265 cites W2001491615 @default.
• W2042263265 cites W2001850627 @default.
• W2042263265 cites W2002276438 @default.
• W2042263265 cites W2002322119 @default.
• W2042263265 cites W2002430564 @default.
• W2042263265 cites W2002844015 @default.
• W2042263265 cites W2003488688 @default.
• W2042263265 cites W2003806209 @default.
• W2042263265 cites W2004425853 @default.

• next