FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042263670> ?p ?o ?g. }

• W2042263670 endingPage "250" @default.
• W2042263670 startingPage "244" @default.
• W2042263670 abstract "Monocytes express cytotoxic factors of the tumour necrosis factor (TNF) ligand superfamily, including TNF and Fas ligand, both on the cell surface and in secreted form. In this report, we show that human monocytes and monocyte-derived macrophages stimulated with lipopolysaccharide (LPS) express APO2 ligand (APO2L, TRAIL), a recently discovered cytotoxic member of the TNF ligand superfamily. LPS increased the transcription of APO2L mRNA in monocytes and macrophages. Flow cytometric analysis showed low surface and high intracellular levels of APO2L, and LPS increased the expression of both. In addition, LPS increased the monocyte- and macrophage-mediated cytotoxicity against the APO2L-sensitive Jurkat and RPMI-8226 cells. Addition of the APO2L-binding decoy receptor 1 (DcR1)-Fc fusion protein inhibited the cytotoxicity by 30-70%. LPS also stimulated the release of soluble APO2L from the monocytes and macrophages. Monocytic phagocytosis of target cells was increased by LPS and partially inhibited by DcR1-Fc. Taken together, these data demonstrate a novel mechanism of cytotoxicity mediated by LPS-activated human monocytes and macrophages." @default.
• W2042263670 created "2016-06-24" @default.
• W2042263670 creator A5028133447 @default.
• W2042263670 creator A5031856620 @default.
• W2042263670 creator A5060203616 @default.
• W2042263670 creator A5069390047 @default.
• W2042263670 date "2000-03-01" @default.
• W2042263670 modified "2023-10-16" @default.
• W2042263670 title "Lipopolysaccharide Induces Expression of APO2 Ligand/TRAIL in Human Monocytes and Macrophages" @default.
• W2042263670 cites W105127712 @default.
• W2042263670 cites W1969411212 @default.
• W2042263670 cites W1973848893 @default.
• W2042263670 cites W1988854695 @default.
• W2042263670 cites W1989600187 @default.
• W2042263670 cites W2008794819 @default.
• W2042263670 cites W2019288826 @default.
• W2042263670 cites W2025128734 @default.
• W2042263670 cites W2030508115 @default.
• W2042263670 cites W2050007366 @default.
• W2042263670 cites W2055905844 @default.
• W2042263670 cites W2056217426 @default.
• W2042263670 cites W2070807737 @default.
• W2042263670 cites W2076719655 @default.
• W2042263670 cites W2101657738 @default.
• W2042263670 cites W2130988210 @default.
• W2042263670 cites W2140288892 @default.
• W2042263670 cites W2149102487 @default.
• W2042263670 cites W2169439167 @default.
• W2042263670 cites W2313795052 @default.
• W2042263670 cites W4236031369 @default.
• W2042263670 cites W4252615446 @default.
• W2042263670 doi "https://doi.org/10.1046/j.1365-3083.2000.00671.x" @default.
• W2042263670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10736093" @default.
• W2042263670 hasPublicationYear "2000" @default.
• W2042263670 type Work @default.
• W2042263670 sameAs 2042263670 @default.
• W2042263670 citedByCount "90" @default.
• W2042263670 countsByYear W20422636702012 @default.
• W2042263670 countsByYear W20422636702013 @default.
• W2042263670 countsByYear W20422636702014 @default.
• W2042263670 countsByYear W20422636702015 @default.
• W2042263670 countsByYear W20422636702016 @default.
• W2042263670 countsByYear W20422636702017 @default.
• W2042263670 countsByYear W20422636702019 @default.
• W2042263670 countsByYear W20422636702020 @default.
• W2042263670 countsByYear W20422636702021 @default.
• W2042263670 countsByYear W20422636702022 @default.
• W2042263670 countsByYear W20422636702023 @default.
• W2042263670 crossrefType "journal-article" @default.
• W2042263670 hasAuthorship W2042263670A5028133447 @default.
• W2042263670 hasAuthorship W2042263670A5031856620 @default.
• W2042263670 hasAuthorship W2042263670A5060203616 @default.
• W2042263670 hasAuthorship W2042263670A5069390047 @default.
• W2042263670 hasConcept C108634530 @default.
• W2042263670 hasConcept C109316439 @default.
• W2042263670 hasConcept C116569031 @default.
• W2042263670 hasConcept C153911025 @default.
• W2042263670 hasConcept C154317977 @default.
• W2042263670 hasConcept C160448771 @default.
• W2042263670 hasConcept C170493617 @default.
• W2042263670 hasConcept C179464577 @default.
• W2042263670 hasConcept C17991360 @default.
• W2042263670 hasConcept C185592680 @default.
• W2042263670 hasConcept C202751555 @default.
• W2042263670 hasConcept C203014093 @default.
• W2042263670 hasConcept C2776090121 @default.
• W2042263670 hasConcept C2778754761 @default.
• W2042263670 hasConcept C2779244956 @default.
• W2042263670 hasConcept C2781184567 @default.
• W2042263670 hasConcept C55493867 @default.
• W2042263670 hasConcept C86803240 @default.
• W2042263670 hasConcept C8891405 @default.
• W2042263670 hasConcept C95444343 @default.
• W2042263670 hasConceptScore W2042263670C108634530 @default.
• W2042263670 hasConceptScore W2042263670C109316439 @default.
• W2042263670 hasConceptScore W2042263670C116569031 @default.
• W2042263670 hasConceptScore W2042263670C153911025 @default.
• W2042263670 hasConceptScore W2042263670C154317977 @default.
• W2042263670 hasConceptScore W2042263670C160448771 @default.
• W2042263670 hasConceptScore W2042263670C170493617 @default.
• W2042263670 hasConceptScore W2042263670C179464577 @default.
• W2042263670 hasConceptScore W2042263670C17991360 @default.
• W2042263670 hasConceptScore W2042263670C185592680 @default.
• W2042263670 hasConceptScore W2042263670C202751555 @default.
• W2042263670 hasConceptScore W2042263670C203014093 @default.
• W2042263670 hasConceptScore W2042263670C2776090121 @default.
• W2042263670 hasConceptScore W2042263670C2778754761 @default.
• W2042263670 hasConceptScore W2042263670C2779244956 @default.
• W2042263670 hasConceptScore W2042263670C2781184567 @default.
• W2042263670 hasConceptScore W2042263670C55493867 @default.
• W2042263670 hasConceptScore W2042263670C86803240 @default.
• W2042263670 hasConceptScore W2042263670C8891405 @default.
• W2042263670 hasConceptScore W2042263670C95444343 @default.
• W2042263670 hasIssue "3" @default.
• W2042263670 hasLocation W20422636701 @default.
• W2042263670 hasLocation W20422636702 @default.
• W2042263670 hasOpenAccess W2042263670 @default.
• W2042263670 hasPrimaryLocation W20422636701 @default.

• next