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• W2042271008 abstract "We enrolled 2,625 human immunodeficiency virus-infected patients into a randomized trial to assess the efficacy and tolerability of daily vs. thrice-weekly trimethoprim-sulfamethoxazole (160 mg/800 mg) for prophylaxis of Pneumocystis carinii pneumonia (PCP). The rate of PCP was 3.5 and 4.1 per 100 person-years in the daily and thrice-weekly groups, respectively, with a relative risk (RR) of 0.82 (95% confidence interval [CI], 0.61-1.09; P = .16) (RR of <1.0 favors daily trimethoprim-sulfamethoxazole). The RR for PCP determined by on-treatment analysis was 0.59 (P = .03). The RR for death was 0.91 (P = .12); for bacterial pneumonia, 0.82 (P = .06); and for combined PCP and bacterial pneumonia, 0.84 (P = .04). Discontinuation due to adverse events occurred more commonly in the daily trimethoprim-sulfamethoxazole group (RR, 2.14; 95% CI, 1.73-2.66; P < .001). Overall estimates for efficacy end points favored daily trimethoprim-sulfamethoxazole, although rates of intolerance were higher among patients receiving that dose. Daily trimethoprim-sulfamethoxazole may offer advantages as a first choice for PCP prophylaxis; thrice-weekly dosing is an appropriate option for patients intolerant of the daily dose." @default.
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• W2042271008 date "1999-10-01" @default.
• W2042271008 modified "2023-10-18" @default.
• W2042271008 title "A Randomized Trial of Daily and Thrice‐Weekly Trimethoprim‐Sulfamethoxazole for the Prevention of<i>Pneumocystis carinii</i>Pneumonia in Human Immunodeficiency Virus‐Infected Persons" @default.
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• W2042271008 doi "https://doi.org/10.1086/520433" @default.
• W2042271008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10589887" @default.
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