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- W2042282020 abstract "In the two previous papers in this series, age-related differences in ocular tissue size and protein binding were investigated relative to the distribution of drug within the eye. The present paper deals with another potentially important determinant of ocular drug disposition, namely corneal permeability. An in vitro technique was utilized to study the corneal permeability of pilocarpine in rabbits of two different ages. The effect of pH on pilocarpine transport was also examined. Results indicate that the transport of ionized pilocarpine contributes significantly to the overall corneal permeation of pilocarpine. There appears to be no difference in the transport characteristics in corneas of the two ages as far as ionized pilocarpine is concerned. However, the corneas of the younger animals are more permeable to non-ionized pilocarpine than those of 60-day-old rabbits. These results suggest that different pathways or layers in the cornea are rate-limiting for the transport of ionized and unionized pilocarpine. Furthermore, the significant transport of ionized species observed in these studies indicates that the pH-partition hypothesis is not totally adequate to explain the corneal transport of pilocarpine in this particular system." @default.
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- W2042282020 date "1983-09-01" @default.
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- W2042282020 title "Age-related differences in ophthalmic drug disposition III. Corneal permeability of pilocarpine in rabbits" @default.
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- W2042282020 doi "https://doi.org/10.1016/0378-5173(83)90057-1" @default.
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