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- W2042289254 abstract "Based upon the known high toxicity and high antagonist activity of t-butylorthobenzoates towards the GABA receptor complex, 4-t-butyl-1-(4-iodophenyl)-2,6,7-trioxabicyclo[2.2.2]octane 5 and its radioiodo analogues ([123I]-5 and [131I]-5 were prepared as potential markers for the gated chloride channel of GABAA receptors. Mice showed rapid clearance of [131I]-5 from all organs including the brain. The radioactivity was found to proceed into the urine in spite of the high lipophilicity of 5, the high binding affinity of 5 for plasma protein and the apparent chemical stability of 5 in plasma." @default.
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- W2042289254 date "1993-05-01" @default.
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- W2042289254 title "A Potential imaging agent for the GABAA receptor: 4-t-butyl-1-(4-[123I]iodophenyl)-2, 6,7-trioxabicyclo-[2.2.2]octane" @default.
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- W2042289254 doi "https://doi.org/10.1016/0969-8051(93)90078-9" @default.
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