FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042291506> ?p ?o ?g. }

• W2042291506 endingPage "e16551" @default.
• W2042291506 startingPage "e16551" @default.
• W2042291506 abstract "HIV/HCV coinfected individuals under highly active antiretroviral therapy (HAART) represent an interesting model for the investigation of the role played by the immune system in driving the evolution of the HCV quasispecies. We prospectively studied the intra-host evolution of the HCV heterogeneity in 8 coinfected subjects, selected from a cohort of 32 patients initiating HAART: 5 immunological responders (group A) and 3 immunological non-responders (group B), and in two HCV singly infected controls not assuming drugs (group C). For all these subjects at least two serial samples obtained at the first observation (before HAART) and more than 1 year later, underwent clonal sequence analysis of partial E1/E2 sequences, encompassing the whole HVR1. Evolutionary rates, dated phylogenies and population dynamics were co-estimated by using a Bayesian Markov Chain Monte Carlo approach, and site specific selection pressures were estimated by maximum likelihood-based methods. The intra-host evolutionary rates of HCV quasispecies was 10 times higher in subjects treated with HAART than in controls without immunodeficiency (1.9 and 2.3×10−3 sub/site/month in group A and B and 0.29×10−3 sub/site/month in group C individuals). The within-host Bayesian Skyline plot analysis showed an exponential growth of the quasispecies populations in immunological responders, coinciding with a peak in CD4 cell counts. On the contrary, quasispecies population remained constant in group B and in group C controls. A significant positive selection pressure was detected in a half of the patients under HAART and in none of the group C controls. Several sites under significant positive selection were described, mainly included in the HVR1. Our data indicate that different forces, in addition to the selection pressure, drive an exceptionally fast evolution of HCV during HAART immune restoration. We hypothesize that an important role is played by the enlargement of the viral replicative space." @default.
• W2042291506 created "2016-06-24" @default.
• W2042291506 creator A5009479812 @default.
• W2042291506 creator A5011742268 @default.
• W2042291506 creator A5017491062 @default.
• W2042291506 creator A5021218221 @default.
• W2042291506 creator A5026508012 @default.
• W2042291506 creator A5043751045 @default.
• W2042291506 creator A5049754447 @default.
• W2042291506 creator A5065051751 @default.
• W2042291506 creator A5072223346 @default.
• W2042291506 date "2011-01-31" @default.
• W2042291506 modified "2023-10-16" @default.
• W2042291506 title "Within-Host Dynamics of the Hepatitis C Virus Quasispecies Population in HIV-1/HCV Coinfected Patients" @default.
• W2042291506 cites W1731793016 @default.
• W2042291506 cites W1965251469 @default.
• W2042291506 cites W1968494119 @default.
• W2042291506 cites W1973155124 @default.
• W2042291506 cites W1999206566 @default.
• W2042291506 cites W2001634163 @default.
• W2042291506 cites W2008635309 @default.
• W2042291506 cites W2009596137 @default.
• W2042291506 cites W2015489330 @default.
• W2042291506 cites W2021158901 @default.
• W2042291506 cites W2037076542 @default.
• W2042291506 cites W2039071051 @default.
• W2042291506 cites W2040422602 @default.
• W2042291506 cites W2042994480 @default.
• W2042291506 cites W2056839660 @default.
• W2042291506 cites W2081737935 @default.
• W2042291506 cites W2082928585 @default.
• W2042291506 cites W2087895317 @default.
• W2042291506 cites W2092637586 @default.
• W2042291506 cites W2094206246 @default.
• W2042291506 cites W2105585336 @default.
• W2042291506 cites W2106882534 @default.
• W2042291506 cites W2110835349 @default.
• W2042291506 cites W2111374249 @default.
• W2042291506 cites W2112011866 @default.
• W2042291506 cites W2112251725 @default.
• W2042291506 cites W2113368354 @default.
• W2042291506 cites W2115011276 @default.
• W2042291506 cites W2128338137 @default.
• W2042291506 cites W2132341678 @default.
• W2042291506 cites W2136847298 @default.
• W2042291506 cites W2137284430 @default.
• W2042291506 cites W2137901368 @default.
• W2042291506 cites W2137984149 @default.
• W2042291506 cites W2138178197 @default.
• W2042291506 cites W2138477256 @default.
• W2042291506 cites W2141398361 @default.
• W2042291506 cites W2141513016 @default.
• W2042291506 cites W2141913814 @default.
• W2042291506 cites W2142773663 @default.
• W2042291506 cites W2148314976 @default.
• W2042291506 cites W2150789185 @default.
• W2042291506 cites W2159516261 @default.
• W2042291506 cites W2163323132 @default.
• W2042291506 cites W2164334111 @default.
• W2042291506 cites W2166454287 @default.
• W2042291506 cites W2167280005 @default.
• W2042291506 cites W2167739504 @default.
• W2042291506 cites W2169203796 @default.
• W2042291506 cites W2323333247 @default.
• W2042291506 cites W2415964198 @default.
• W2042291506 doi "https://doi.org/10.1371/journal.pone.0016551" @default.
• W2042291506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3031583" @default.
• W2042291506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21304985" @default.
• W2042291506 hasPublicationYear "2011" @default.
• W2042291506 type Work @default.
• W2042291506 sameAs 2042291506 @default.
• W2042291506 citedByCount "21" @default.
• W2042291506 countsByYear W20422915062012 @default.
• W2042291506 countsByYear W20422915062013 @default.
• W2042291506 countsByYear W20422915062014 @default.
• W2042291506 countsByYear W20422915062015 @default.
• W2042291506 countsByYear W20422915062016 @default.
• W2042291506 countsByYear W20422915062017 @default.
• W2042291506 countsByYear W20422915062018 @default.
• W2042291506 countsByYear W20422915062019 @default.
• W2042291506 countsByYear W20422915062020 @default.
• W2042291506 countsByYear W20422915062021 @default.
• W2042291506 crossrefType "journal-article" @default.
• W2042291506 hasAuthorship W2042291506A5009479812 @default.
• W2042291506 hasAuthorship W2042291506A5011742268 @default.
• W2042291506 hasAuthorship W2042291506A5017491062 @default.
• W2042291506 hasAuthorship W2042291506A5021218221 @default.
• W2042291506 hasAuthorship W2042291506A5026508012 @default.
• W2042291506 hasAuthorship W2042291506A5043751045 @default.
• W2042291506 hasAuthorship W2042291506A5049754447 @default.
• W2042291506 hasAuthorship W2042291506A5065051751 @default.
• W2042291506 hasAuthorship W2042291506A5072223346 @default.
• W2042291506 hasBestOaLocation W20422915061 @default.
• W2042291506 hasConcept C104317684 @default.
• W2042291506 hasConcept C126322002 @default.
• W2042291506 hasConcept C141231307 @default.
• W2042291506 hasConcept C14500911 @default.
• W2042291506 hasConcept C159047783 @default.

• next