Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042293318> ?p ?o ?g. }
- W2042293318 endingPage "131" @default.
- W2042293318 startingPage "93" @default.
- W2042293318 abstract "IGF-1 plays important roles in mammalian fertility by promoting cell growth and increasing steroid hormone secretion. Although IGF-1 significantly upregulated luteinizing hormone/choriogonadotropin receptor (LHCGR) gene expression in granulosa cells in a previous study, the mechanism was unclear. The present experiment was designed to primarily explore the regulation of LHCGR expression by IGF-1. First, based on a porcine LHCGR double-luciferase reporter experiment, c-Fos significantly inhibited the activity of the LHCGR promoter. Second, porcine granulosa cells were cultured in vitro with IGF-1, and we observed that the expression of LHCGR was significantly increased and the expression of c-Fos mRNA significantly reduced. After c-Fos overexpression in granulosa cells, IGF-1 attenuated the inhibitory effect of c-Fos on LHCGR. Furthermore, the level of LHCGR mRNA stimulated by IGF-1 in the presence of SB203580 was markedly lower than that of IGF-1 alone action. In conclusion, IGF-1 enhanced the expression of LHCGR by regulating c-Fos in granulosa cells, which may be mediated by the p38MAPK-signaling pathway." @default.
- W2042293318 created "2016-06-24" @default.
- W2042293318 creator A5053005464 @default.
- W2042293318 creator A5057509693 @default.
- W2042293318 date "1994-10-01" @default.
- W2042293318 modified "2023-10-08" @default.
- W2042293318 title "c-fos proto-oncogene regulation and function" @default.
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