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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042301166> ?p ?o ?g. }

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• W2042301166 startingPage "368" @default.
• W2042301166 abstract "Four new flavones, 5,2'-dihydroxy-7,3',4',5'-tetramethoxyflavone (1), 5,2',5'-trihydroxy-7,3',4'-trimethoxyflavone (2), 5,7,2',5'-tetrahydroxy-6,3',4'-trimethoxyflavone (3) and 5,2',5'-trihydroxy-6,7,3',4'-tetramethoxyflavone (4), along with the known 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (5), 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase." @default.
• W2042301166 created "2016-06-24" @default.
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• W2042301166 date "2012-03-01" @default.
• W2042301166 modified "2023-09-26" @default.
• W2042301166 title "DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata" @default.
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• W2042301166 doi "https://doi.org/10.1016/j.fitote.2011.11.015" @default.
• W2042301166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155186" @default.
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